Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells

HuR (ELAVL1), a RNA-binding protein, plays a key role in posttranscriptional regulation of multidrug resistance (MDR)-related genes. Among various HuR-regulated oncogenic transcripts, the activation of galectin-3/β-catenin survival pathway is critical to induce transcription of cyclin D1, P-glycopro...

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Detalles Bibliográficos
Autores principales: Lin, Guan-Liang, Ting, Huei-Ju, Tseng, Ta-Chien, Juang, Vivian, Lo, Yu-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624618/
https://www.ncbi.nlm.nih.gov/pubmed/28968471
http://dx.doi.org/10.1371/journal.pone.0185625

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