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Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxygen homeostasis and regulate specific aspects of hypoxic adaptation. Here we show the importance of HIF-2α dependant signallin...

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Detalles Bibliográficos
Autores principales:	Martín-Aragón Baudel, Miguel A. S., Rae, Mick T., Darlison, Mark G., Poole, Amy V., Fraser, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624621/ https://www.ncbi.nlm.nih.gov/pubmed/28968430 http://dx.doi.org/10.1371/journal.pone.0185664

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