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A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients

BACKGROUND: In end-stage cancer, bleeding may markedly influence the patient’s quality of life, and radiotherapy plays an important role in the control of the bleeding. In particular, there is no clear evidence of the benefit of palliative radiotherapy for cancers including gastric, rectal, and blad...

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Autores principales: Kosugi, Takashi, Shikama, Naoto, Saito, Tetsuo, Nakamura, Naoki, Nakura, Ayako, Harada, Hideyuki, Wada, Hitoshi, Nozaki, Miwako, Uchida, Nobue, Nakamura, Katsumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624693/
https://www.ncbi.nlm.nih.gov/pubmed/28983360
http://dx.doi.org/10.14740/wjon977w
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author Kosugi, Takashi
Shikama, Naoto
Saito, Tetsuo
Nakamura, Naoki
Nakura, Ayako
Harada, Hideyuki
Wada, Hitoshi
Nozaki, Miwako
Uchida, Nobue
Nakamura, Katsumasa
author_facet Kosugi, Takashi
Shikama, Naoto
Saito, Tetsuo
Nakamura, Naoki
Nakura, Ayako
Harada, Hideyuki
Wada, Hitoshi
Nozaki, Miwako
Uchida, Nobue
Nakamura, Katsumasa
author_sort Kosugi, Takashi
collection PubMed
description BACKGROUND: In end-stage cancer, bleeding may markedly influence the patient’s quality of life, and radiotherapy plays an important role in the control of the bleeding. In particular, there is no clear evidence of the benefit of palliative radiotherapy for cancers including gastric, rectal, and bladder cancers. A clarification of the current status of palliative radiotherapy for bleeding is needed. METHODS: A survey was conducted by the palliative radiotherapy working group of the Japanese Radiation Oncology Study Group (JROSG), focusing on annual cases of radiotherapy for tumors of the upper and lower gastrointestinal tracts and genitourinary organs (excluding the uterus) and applicable fractionated doses for three hypothetical patients. RESULTS: A total of 54 radiation oncologists at 43 facilities answered. Most of the facilities reported that they conducted hemostatic irradiation for less than one patient per year, though the median annual number of patients treated with radiotherapy in these facilities was 594. The most frequently observed doses per fraction for two of the hypothetical cases were 3.0 and 2.0 Gy. On the other hand, in each case, the numbers of fractions reported varied markedly among the respondents, ranging from 20 Gy in five fractions to over 30 fractions. CONCLUSIONS: Especially in gastric cancer, hemostatic irradiation is rarely performed in most facilities in Japan. An optimal dose fractionation has not been established. Thirty Gy in 10 fractions is one of the most frequently used regimens, but re-bleeding was observed in approximately one-third of the patients.
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spelling pubmed-56246932017-10-05 A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients Kosugi, Takashi Shikama, Naoto Saito, Tetsuo Nakamura, Naoki Nakura, Ayako Harada, Hideyuki Wada, Hitoshi Nozaki, Miwako Uchida, Nobue Nakamura, Katsumasa World J Oncol Original Article BACKGROUND: In end-stage cancer, bleeding may markedly influence the patient’s quality of life, and radiotherapy plays an important role in the control of the bleeding. In particular, there is no clear evidence of the benefit of palliative radiotherapy for cancers including gastric, rectal, and bladder cancers. A clarification of the current status of palliative radiotherapy for bleeding is needed. METHODS: A survey was conducted by the palliative radiotherapy working group of the Japanese Radiation Oncology Study Group (JROSG), focusing on annual cases of radiotherapy for tumors of the upper and lower gastrointestinal tracts and genitourinary organs (excluding the uterus) and applicable fractionated doses for three hypothetical patients. RESULTS: A total of 54 radiation oncologists at 43 facilities answered. Most of the facilities reported that they conducted hemostatic irradiation for less than one patient per year, though the median annual number of patients treated with radiotherapy in these facilities was 594. The most frequently observed doses per fraction for two of the hypothetical cases were 3.0 and 2.0 Gy. On the other hand, in each case, the numbers of fractions reported varied markedly among the respondents, ranging from 20 Gy in five fractions to over 30 fractions. CONCLUSIONS: Especially in gastric cancer, hemostatic irradiation is rarely performed in most facilities in Japan. An optimal dose fractionation has not been established. Thirty Gy in 10 fractions is one of the most frequently used regimens, but re-bleeding was observed in approximately one-third of the patients. Elmer Press 2016-06 2016-07-01 /pmc/articles/PMC5624693/ /pubmed/28983360 http://dx.doi.org/10.14740/wjon977w Text en Copyright 2016, Kosugi et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kosugi, Takashi
Shikama, Naoto
Saito, Tetsuo
Nakamura, Naoki
Nakura, Ayako
Harada, Hideyuki
Wada, Hitoshi
Nozaki, Miwako
Uchida, Nobue
Nakamura, Katsumasa
A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title_full A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title_fullStr A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title_full_unstemmed A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title_short A Nationwide Survey in Japan of Palliative Radiotherapy for Bleeding in Gastrointestinal and Genitourinary Tumor Patients
title_sort nationwide survey in japan of palliative radiotherapy for bleeding in gastrointestinal and genitourinary tumor patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624693/
https://www.ncbi.nlm.nih.gov/pubmed/28983360
http://dx.doi.org/10.14740/wjon977w
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