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A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma

A 62-year-old man with a complaint of back pain lasting 2 months was admitted. He also presented a huge abdominal tumor. Diagnostic imaging showed metastatic tumors in the liver, lumbar vertebrae and bilateral lung. An ultrasound-guided needle biopsy revealed a lung tumor containing melanic tissue....

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Autores principales: Takeuchi, Nobumichi, Miyazawa, Shun, Ohno, Zentaro, Yoshida, Sonomi, Tsukamoto, Tetsu, Fujiwara, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624695/
https://www.ncbi.nlm.nih.gov/pubmed/28983362
http://dx.doi.org/10.14740/wjon970w
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author Takeuchi, Nobumichi
Miyazawa, Shun
Ohno, Zentaro
Yoshida, Sonomi
Tsukamoto, Tetsu
Fujiwara, Masayuki
author_facet Takeuchi, Nobumichi
Miyazawa, Shun
Ohno, Zentaro
Yoshida, Sonomi
Tsukamoto, Tetsu
Fujiwara, Masayuki
author_sort Takeuchi, Nobumichi
collection PubMed
description A 62-year-old man with a complaint of back pain lasting 2 months was admitted. He also presented a huge abdominal tumor. Diagnostic imaging showed metastatic tumors in the liver, lumbar vertebrae and bilateral lung. An ultrasound-guided needle biopsy revealed a lung tumor containing melanic tissue. Subsequently, there was an evident elevation in uric acid, phosphoric acid, potassium and lactate dehydrogenase concentrations in serum. Continuous hemodiafiltration and administration of rasburicase was initiated following the diagnosis of tumor lysis syndrome (TLS). However, he died on the fourth day owing to arrhythmia. An autopsy revealed metastatic deposits in the liver, lung, spine, ribs, and lymph nodes along the biliary system. Microscopic examinations revealed massive necrosis of normal hepatocytes and tumor cells with disseminated tumor thrombi in the portal system. The catastrophic progression of TLS appears to be influenced by a persistent portal blood flow deficiency by portal tumor thrombus in this case.
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spelling pubmed-56246952017-10-05 A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma Takeuchi, Nobumichi Miyazawa, Shun Ohno, Zentaro Yoshida, Sonomi Tsukamoto, Tetsu Fujiwara, Masayuki World J Oncol Case Report A 62-year-old man with a complaint of back pain lasting 2 months was admitted. He also presented a huge abdominal tumor. Diagnostic imaging showed metastatic tumors in the liver, lumbar vertebrae and bilateral lung. An ultrasound-guided needle biopsy revealed a lung tumor containing melanic tissue. Subsequently, there was an evident elevation in uric acid, phosphoric acid, potassium and lactate dehydrogenase concentrations in serum. Continuous hemodiafiltration and administration of rasburicase was initiated following the diagnosis of tumor lysis syndrome (TLS). However, he died on the fourth day owing to arrhythmia. An autopsy revealed metastatic deposits in the liver, lung, spine, ribs, and lymph nodes along the biliary system. Microscopic examinations revealed massive necrosis of normal hepatocytes and tumor cells with disseminated tumor thrombi in the portal system. The catastrophic progression of TLS appears to be influenced by a persistent portal blood flow deficiency by portal tumor thrombus in this case. Elmer Press 2016-06 2016-07-01 /pmc/articles/PMC5624695/ /pubmed/28983362 http://dx.doi.org/10.14740/wjon970w Text en Copyright 2016, Takeuchi et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Takeuchi, Nobumichi
Miyazawa, Shun
Ohno, Zentaro
Yoshida, Sonomi
Tsukamoto, Tetsu
Fujiwara, Masayuki
A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title_full A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title_fullStr A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title_full_unstemmed A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title_short A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma
title_sort case of spontaneous tumor lysis syndrome in malignant melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624695/
https://www.ncbi.nlm.nih.gov/pubmed/28983362
http://dx.doi.org/10.14740/wjon970w
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