Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumor cell growth. Despite the...

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Detalles Bibliográficos
Autores principales: Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624783/
https://www.ncbi.nlm.nih.gov/pubmed/28967864
http://dx.doi.org/10.7554/eLife.28083

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