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Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study

BACKGROUND: Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targets pain pathways, and studies have reported different LEP-changes both between...

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Autores principales: Uglem, Martin, Omland, Petter Moe, Stjern, Marit, Gravdahl, Gøril Bruvik, Sand, Trond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624861/
https://www.ncbi.nlm.nih.gov/pubmed/28971336
http://dx.doi.org/10.1186/s10194-017-0810-6
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author Uglem, Martin
Omland, Petter Moe
Stjern, Marit
Gravdahl, Gøril Bruvik
Sand, Trond
author_facet Uglem, Martin
Omland, Petter Moe
Stjern, Marit
Gravdahl, Gøril Bruvik
Sand, Trond
author_sort Uglem, Martin
collection PubMed
description BACKGROUND: Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targets pain pathways, and studies have reported different LEP-changes both between and during headaches. Our primary aim was to explore potential cyclic variations in LEP amplitude and habituation in more detail with a blinded longitudinal study design. METHODS: We compared N1 and N2P2 amplitudes and habituation between two blocks of laser stimulations to the dorsal hand, obtained from 49 migraineurs with four sessions each. We used migraine diaries to categorize sessions as interictal (> one day from previous and to next attack), preictal (< one day before the attack), ictal or postictal (< one day after the attack). Also, we compared 29 interictal recordings from the first session to 30 controls. RESULTS: N1 and N2P2 amplitudes and habituation did not differ between preictal, interictal and postictal phase sessions, except for a post hoc contrast that showed deficient ictal habituation of N1. Habituation is present and similar in migraineurs in the interictal phase and controls. CONCLUSIONS: Hand-evoked LEP amplitudes and habituation were mainly invariable between migraine phases, but this matter needs further study. Because hand-evoked LEP-habituation was similar in migraineurs and controls, the present findings contradict several previous LEP studies. Pain-evoked cerebral responses are normal and show normal habituation in migraine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s10194-017-0810-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-56248612017-10-17 Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study Uglem, Martin Omland, Petter Moe Stjern, Marit Gravdahl, Gøril Bruvik Sand, Trond J Headache Pain Research Article BACKGROUND: Migraineurs seem to have cyclic variations in cortical excitability in several neurophysiological modalities. Laser-evoked potentials (LEP) are of particular interest in migraine because LEP specifically targets pain pathways, and studies have reported different LEP-changes both between and during headaches. Our primary aim was to explore potential cyclic variations in LEP amplitude and habituation in more detail with a blinded longitudinal study design. METHODS: We compared N1 and N2P2 amplitudes and habituation between two blocks of laser stimulations to the dorsal hand, obtained from 49 migraineurs with four sessions each. We used migraine diaries to categorize sessions as interictal (> one day from previous and to next attack), preictal (< one day before the attack), ictal or postictal (< one day after the attack). Also, we compared 29 interictal recordings from the first session to 30 controls. RESULTS: N1 and N2P2 amplitudes and habituation did not differ between preictal, interictal and postictal phase sessions, except for a post hoc contrast that showed deficient ictal habituation of N1. Habituation is present and similar in migraineurs in the interictal phase and controls. CONCLUSIONS: Hand-evoked LEP amplitudes and habituation were mainly invariable between migraine phases, but this matter needs further study. Because hand-evoked LEP-habituation was similar in migraineurs and controls, the present findings contradict several previous LEP studies. Pain-evoked cerebral responses are normal and show normal habituation in migraine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s10194-017-0810-6) contains supplementary material, which is available to authorized users. Springer Milan 2017-10-02 /pmc/articles/PMC5624861/ /pubmed/28971336 http://dx.doi.org/10.1186/s10194-017-0810-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Uglem, Martin
Omland, Petter Moe
Stjern, Marit
Gravdahl, Gøril Bruvik
Sand, Trond
Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title_full Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title_fullStr Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title_full_unstemmed Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title_short Habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
title_sort habituation of laser-evoked potentials by migraine phase: a blinded longitudinal study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624861/
https://www.ncbi.nlm.nih.gov/pubmed/28971336
http://dx.doi.org/10.1186/s10194-017-0810-6
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