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Long Non-coding RNAs in Hepatitis C Virus-Infected Cells

Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long...

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Autores principales: Barriocanal, Marina, Fortes, Puri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625025/
https://www.ncbi.nlm.nih.gov/pubmed/29033906
http://dx.doi.org/10.3389/fmicb.2017.01833
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author Barriocanal, Marina
Fortes, Puri
author_facet Barriocanal, Marina
Fortes, Puri
author_sort Barriocanal, Marina
collection PubMed
description Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs. Some of these are also deregulated in response to viral replication. Certain viral proteins and/or viral replication can activate transcription factors such as MYC, SP1, NRF2, or HIF1α that modulate the expression of additional cellular lncRNAs. Interestingly, several lncRNAs deregulated in HCV-infected cells described so far play proviral or antiviral functions by acting as positive or negative regulators of the IFN system, while others help in the development of liver cirrhosis and HCC. The study of the structure and mechanism of action of these lncRNAs may aid in the development of novel strategies to treat infectious and immune pathologies and liver diseases such as cirrhosis and HCC.
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spelling pubmed-56250252017-10-13 Long Non-coding RNAs in Hepatitis C Virus-Infected Cells Barriocanal, Marina Fortes, Puri Front Microbiol Microbiology Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs. Some of these are also deregulated in response to viral replication. Certain viral proteins and/or viral replication can activate transcription factors such as MYC, SP1, NRF2, or HIF1α that modulate the expression of additional cellular lncRNAs. Interestingly, several lncRNAs deregulated in HCV-infected cells described so far play proviral or antiviral functions by acting as positive or negative regulators of the IFN system, while others help in the development of liver cirrhosis and HCC. The study of the structure and mechanism of action of these lncRNAs may aid in the development of novel strategies to treat infectious and immune pathologies and liver diseases such as cirrhosis and HCC. Frontiers Media S.A. 2017-09-28 /pmc/articles/PMC5625025/ /pubmed/29033906 http://dx.doi.org/10.3389/fmicb.2017.01833 Text en Copyright © 2017 Barriocanal and Fortes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Barriocanal, Marina
Fortes, Puri
Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title_full Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title_fullStr Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title_full_unstemmed Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title_short Long Non-coding RNAs in Hepatitis C Virus-Infected Cells
title_sort long non-coding rnas in hepatitis c virus-infected cells
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625025/
https://www.ncbi.nlm.nih.gov/pubmed/29033906
http://dx.doi.org/10.3389/fmicb.2017.01833
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