Cargando…

Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by motor as well as nonmotor symptoms for which there is currently no cure. The Q175 mouse model of HD recapitulates many of the symptoms identified in HD patients including disruptions of the sleep/wak...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whittaker, Daniel S., Wang, Huei‐Bin, Loh, Dawn H., Cachope, Roger, Colwell, Christopher S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625154/ https://www.ncbi.nlm.nih.gov/pubmed/28971617 http://dx.doi.org/10.1002/prp2.344

Ejemplares similares

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
por: Wang, Huei-Bin, et al.
Publicado: (2018)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Impaired Performance of the Q175 Mouse Model of Huntington’s Disease in the Touch Screen Paired Associates Learning Task
por: Piiponniemi, Tuukka O., et al.
Publicado: (2018)

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep
por: Loh, Dawn H., et al.
Publicado: (2013)

Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease
por: Wang, Huei-Bin, et al.
Publicado: (2017)

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease
por: Quirion, Jade G., et al.
Publicado: (2019)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Nonmotor Symptoms of Parkinson's Disease
por: Rektorova, Irena, et al.
Publicado: (2011)

Nonmotor Symptoms of Parkinson's Disease
por: Wu, Shey-Lin, et al.
Publicado: (2017)

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease
por: Tanimura, Asami, et al.
Publicado: (2016)

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
por: Deng, Yunping, et al.
Publicado: (2020)

Baroreceptor reflex dysfunction in the BACHD mouse model of Huntington’s disease.
por: Schroeder, Analyne M., et al.
Publicado: (2011)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Ceruloplasmin in Parkinson's disease and the nonmotor symptoms
por: Zhao, Xuemei, et al.
Publicado: (2018)

Nonmotor symptoms in spinocerebellar ataxias (SCAs)
por: Moro, Adriana, et al.
Publicado: (2019)

Nonmotor Symptoms in Dystonia: Pathophysiological Implications
por: Mishra, Anumeha, et al.
Publicado: (2020)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability?
por: Takamatsu, Yoshiki, et al.
Publicado: (2018)

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Nonmotor Symptoms in Patients with PARK2 Mutations
por: Yoritaka, Asako, et al.
Publicado: (2011)

Dopamine-Induced Nonmotor Symptoms of Parkinson's Disease
por: Park, Ariane, et al.
Publicado: (2011)

Neuropathology and Neurochemistry of Nonmotor Symptoms in Parkinson's Disease
por: Ferrer, Isidro
Publicado: (2011)

Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and Tremor
por: Evans, Andrew H., et al.
Publicado: (2016)

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy
por: Ou, Ruwei, et al.
Publicado: (2016)

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington’s Disease
por: Kuljis, Dika A., et al.
Publicado: (2016)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175(+/-) mouse model of Huntington’s Disease
por: Goodliffe, Joseph W., et al.
Publicado: (2018)

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease
por: Whittaker, Daniel S., et al.
Publicado: (2022)

Nonmotor Symptoms in a Malaysian Parkinson's Disease Population
por: Azmin, Shahrul, et al.
Publicado: (2014)

Effect of Exercise on Motor and Nonmotor Symptoms of Parkinson's Disease
por: Dashtipour, Khashayar, et al.
Publicado: (2015)

Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction
por: Ferris, Craig F., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_nvls6cikefshvjuou38kehioe4