Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine

Metformin is a common co‐medication for many diseases and the victim of clinical drug‐drug interactions (DDIs) perpetrated by cimetidine, trimethoprim and pyrimethamine, resulting in decreased active renal clearance due to inhibition of organic cation transport proteins and increased plasma exposure...

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Detalles Bibliográficos
Autores principales: Elsby, Robert, Chidlaw, Stephen, Outteridge, Samuel, Pickering, Sarah, Radcliffe, Amy, Sullivan, Rebecca, Jones, Hayley, Butler, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625161/
https://www.ncbi.nlm.nih.gov/pubmed/28971610
http://dx.doi.org/10.1002/prp2.357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625161/
https://www.ncbi.nlm.nih.gov/pubmed/28971610
http://dx.doi.org/10.1002/prp2.357

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