Incompatibility of chemical protein synthesis inhibitors with accurate measurement of extended protein degradation rates

Protein synthesis inhibitors are commonly used for measuring protein degradation rates, but may cause cytotoxicity via direct or indirect mechanisms. This study aimed to identify concentrations providing optimal inhibition in the absence of overt cytotoxicity. Actinomycin D, cycloheximide, emetine,...

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Detalles Bibliográficos
Autores principales: Chan, Christina, Martin, Philip, Liptrott, Neill J., Siccardi, Marco, Almond, Lisa, Owen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625163/
https://www.ncbi.nlm.nih.gov/pubmed/28971619
http://dx.doi.org/10.1002/prp2.359

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