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Nickel-catalyzed C–H/N–H annulation of aromatic amides with alkynes in the absence of a specific chelation system
The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBu(t) involves C–H/N–H oxidative annulation to give 1(2H)-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBu(t). The reaction shows a high functional group...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625264/ https://www.ncbi.nlm.nih.gov/pubmed/28989692 http://dx.doi.org/10.1039/c7sc01750b |