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Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications
Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We sought to determine whether slow off-rate modified apt...
Autores principales: | Russell, Theresa M., Green, Louis S., Rice, Taylor, Kruh-Garcia, Nicole A., Dobos, Karen, De Groote, Mary A., Hraha, Thomas, Sterling, David G., Janjic, Nebojsa, Ochsner, Urs A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625393/ https://www.ncbi.nlm.nih.gov/pubmed/28794178 http://dx.doi.org/10.1128/JCM.00469-17 |
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