Pseudohypercalcemia in Multiple Myeloma: A Case Report

Hypercalcemia is a common finding in patients with multiple myeloma. Clinical manifestations of hypercalcemia correlate with the level of serum calcium. Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. In pseudohypercalcemia the Ionized Ca is normal, although binding of calciu...

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Autores principales: Ashrafi, Farzaneh, Iraj, Bijan, Nematollahi, Pardis, Darakhshandeh, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625476/
https://www.ncbi.nlm.nih.gov/pubmed/28989592
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author Ashrafi, Farzaneh
Iraj, Bijan
Nematollahi, Pardis
Darakhshandeh, Ali
author_facet Ashrafi, Farzaneh
Iraj, Bijan
Nematollahi, Pardis
Darakhshandeh, Ali
author_sort Ashrafi, Farzaneh
collection PubMed
description Hypercalcemia is a common finding in patients with multiple myeloma. Clinical manifestations of hypercalcemia correlate with the level of serum calcium. Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. In pseudohypercalcemia the Ionized Ca is normal, although binding of calcium to abnormal immunoglobulin causes increased serum calcium level. In the asymptomatic multiple myeloma patients with moderate to severe hypercalcemia, measurement of ionized calcium is critical to exclude pseudohypercalcemia. Here, we describe an asymptomatic 44-year-old man with multiple myeloma who had severe hypercalcemia, but normal serum Ionized Ca level.
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spelling pubmed-56254762017-10-06 Pseudohypercalcemia in Multiple Myeloma: A Case Report Ashrafi, Farzaneh Iraj, Bijan Nematollahi, Pardis Darakhshandeh, Ali Int J Hematol Oncol Stem Cell Res Case Report Hypercalcemia is a common finding in patients with multiple myeloma. Clinical manifestations of hypercalcemia correlate with the level of serum calcium. Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. In pseudohypercalcemia the Ionized Ca is normal, although binding of calcium to abnormal immunoglobulin causes increased serum calcium level. In the asymptomatic multiple myeloma patients with moderate to severe hypercalcemia, measurement of ionized calcium is critical to exclude pseudohypercalcemia. Here, we describe an asymptomatic 44-year-old man with multiple myeloma who had severe hypercalcemia, but normal serum Ionized Ca level. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017-07-01 /pmc/articles/PMC5625476/ /pubmed/28989592 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ashrafi, Farzaneh
Iraj, Bijan
Nematollahi, Pardis
Darakhshandeh, Ali
Pseudohypercalcemia in Multiple Myeloma: A Case Report
title Pseudohypercalcemia in Multiple Myeloma: A Case Report
title_full Pseudohypercalcemia in Multiple Myeloma: A Case Report
title_fullStr Pseudohypercalcemia in Multiple Myeloma: A Case Report
title_full_unstemmed Pseudohypercalcemia in Multiple Myeloma: A Case Report
title_short Pseudohypercalcemia in Multiple Myeloma: A Case Report
title_sort pseudohypercalcemia in multiple myeloma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625476/
https://www.ncbi.nlm.nih.gov/pubmed/28989592
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AT nematollahipardis pseudohypercalcemiainmultiplemyelomaacasereport
AT darakhshandehali pseudohypercalcemiainmultiplemyelomaacasereport

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