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Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge
Uterine leiomyosarcoma (ULMS) is a rare malignancy of the female genital tract and carries an extremely poor 5-year survival rate. It is known to metastasize early and to distant sites owing to a high propensity for hematogeneous spread. Lung, peritoneum, liver, and bone are relatively common sites...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625581/ https://www.ncbi.nlm.nih.gov/pubmed/28983164 http://dx.doi.org/10.4103/jmh.JMH_60_17 |
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author | Ahuja, Arvind Agarwal, Poojan Sardana, Rohan Bhaskar, Suryanarayanan |
author_facet | Ahuja, Arvind Agarwal, Poojan Sardana, Rohan Bhaskar, Suryanarayanan |
author_sort | Ahuja, Arvind |
collection | PubMed |
description | Uterine leiomyosarcoma (ULMS) is a rare malignancy of the female genital tract and carries an extremely poor 5-year survival rate. It is known to metastasize early and to distant sites owing to a high propensity for hematogeneous spread. Lung, peritoneum, liver, and bone are relatively common sites of metastasis. Patient age, tumor size, FIGO stage, and grade of the tumor are important criteria for predicting metastasis. The incidence of ULMS is increasing, probably due to the use of improved imaging techniques and as a result of cancer patients' prolonged life expectancy. An early well thought diagnosis is only made possible if even in otherwise seemingly unsuspected cases, the histopathology slides are extensively screened and the treating clinician is alerted timely. We hereby report a case of an elderly female who underwent hysterectomy for resection of multiple fibroids in the uterus and later presented with distant metastasis to brain with the erosion of overlying skull bone, chest wall, and lungs. Microscopic features along with an extensive immunohistochemistry panel were used to ascertain tumor origin. |
format | Online Article Text |
id | pubmed-5625581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56255812017-10-05 Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge Ahuja, Arvind Agarwal, Poojan Sardana, Rohan Bhaskar, Suryanarayanan J Midlife Health Case Report Uterine leiomyosarcoma (ULMS) is a rare malignancy of the female genital tract and carries an extremely poor 5-year survival rate. It is known to metastasize early and to distant sites owing to a high propensity for hematogeneous spread. Lung, peritoneum, liver, and bone are relatively common sites of metastasis. Patient age, tumor size, FIGO stage, and grade of the tumor are important criteria for predicting metastasis. The incidence of ULMS is increasing, probably due to the use of improved imaging techniques and as a result of cancer patients' prolonged life expectancy. An early well thought diagnosis is only made possible if even in otherwise seemingly unsuspected cases, the histopathology slides are extensively screened and the treating clinician is alerted timely. We hereby report a case of an elderly female who underwent hysterectomy for resection of multiple fibroids in the uterus and later presented with distant metastasis to brain with the erosion of overlying skull bone, chest wall, and lungs. Microscopic features along with an extensive immunohistochemistry panel were used to ascertain tumor origin. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5625581/ /pubmed/28983164 http://dx.doi.org/10.4103/jmh.JMH_60_17 Text en Copyright: © 2017 Journal of Mid-life Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Ahuja, Arvind Agarwal, Poojan Sardana, Rohan Bhaskar, Suryanarayanan Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title | Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title_full | Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title_fullStr | Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title_full_unstemmed | Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title_short | Extensively Metastasizing Leiomyosarcoma: A Diagnostic Challenge |
title_sort | extensively metastasizing leiomyosarcoma: a diagnostic challenge |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625581/ https://www.ncbi.nlm.nih.gov/pubmed/28983164 http://dx.doi.org/10.4103/jmh.JMH_60_17 |
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