Cargando…

Characterisation of the cancer-associated glucocorticoid system: key role of 11β-hydroxysteroid dehydrogenase type 2

BACKGROUND: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and cortisol is regulated by the 11β-hydroxysteroid dehydrogenases (11β-HSDs). However, li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cirillo, Nicola, Morgan, David J, Pedicillo, Maria Carmela, Celentano, Antonio, Lo Muzio, Lorenzo, McCullough, Michael J, Prime, Stephen S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625663/ https://www.ncbi.nlm.nih.gov/pubmed/28797028 http://dx.doi.org/10.1038/bjc.2017.243

Ejemplares similares

17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer
por: Gunnarsson, C, et al.
Publicado: (2005)

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion
por: Hassona, Y, et al.
Publicado: (2014)

Changes in 11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Expression in Kawasaki Disease
por: Wang, Juanli, et al.
Publicado: (2017)

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
por: Morgan, Stuart A., et al.
Publicado: (2009)

Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids
por: Atanasov, Atanas G., et al.
Publicado: (2005)

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation
por: Chapman, Karen E., et al.
Publicado: (2013)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders
por: Dodd, Seetal, et al.
Publicado: (2022)

Characterisation and protein expression profiling of annexins in colorectal cancer
por: Duncan, R, et al.
Publicado: (2008)

Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis
por: Yan, J, et al.
Publicado: (2014)

Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism
por: Beesley, A H, et al.
Publicado: (2009)

Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
por: Sung, Hyuna, et al.
Publicado: (2016)

11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells
por: Lee, Sang Eun, et al.
Publicado: (2017)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

Characterisation of PD-L1-positive subsets of microsatellite-unstable colorectal cancers
por: Kim, Jung Ho, et al.
Publicado: (2016)

Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer
por: Matsumoto, Akiko, et al.
Publicado: (2017)

Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
por: Meng, X N, et al.
Publicado: (2009)

Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone
por: Endo-Munoz, L, et al.
Publicado: (2010)

Urinary EpCAM in urothelial bladder cancer patients: characterisation and evaluation of biomarker potential
por: Bryan, R T, et al.
Publicado: (2014)

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
por: Maftouh, M, et al.
Publicado: (2014)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

Alteration of 11β-Hydroxysteroid Dehydrogenase Type 1 and Glucocorticoid Receptor by Ethanol in Rat Liver and Mouse Hepatoma Cells
por: Meng, Zhaojie, et al.
Publicado: (2013)

A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei
por: Bibi, R, et al.
Publicado: (2006)

Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours
por: Salto-Tellez, M, et al.
Publicado: (2007)

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer
por: Salcido, C D, et al.
Publicado: (2010)

Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness
por: Weiswald, L-B, et al.
Publicado: (2009)

The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma
por: Giannopoulos, K, et al.
Publicado: (2012)

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
por: Lauvrak, S U, et al.
Publicado: (2013)

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
por: Markey, Keira A, et al.
Publicado: (2016)

Cortisol, Hypertension and Obesity: The Role of 11β-Hydroxysteroid Dehydrogenase
por: Stewart, Paul M
Publicado: (1998)

Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
por: Bujalska, Iwona J, et al.
Publicado: (2007)

Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer
por: Flores, L M, et al.
Publicado: (2010)

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer
por: Nalwoga, H, et al.
Publicado: (2010)

Characterisation of blood-derived exosomal hTERT mRNA secretion in cancer patients: a potential pan-cancer marker
por: Goldvaser, Hadar, et al.
Publicado: (2017)

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids
por: Suhana Mohd Ramli, Elvy, et al.
Publicado: (2012)

Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma
por: Wang, T, et al.
Publicado: (2010)

Semiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting
por: Peeters, D J E, et al.
Publicado: (2013)

Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer
por: Matsubara, J, et al.
Publicado: (2008)

Effect of Luteolin on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
por: Tang, Lei, et al.
Publicado: (2015)

Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
por: Wang, Yiyan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0mvs23u6e2jhvhjd3vpsuqdn92