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Influence of dietary insulin scores on survival in colorectal cancer patients

BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival. METHODS: We examined the association of post-diagnosis dietary insulin scores with s...

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Autores principales: Yuan, Chen, Bao, Ying, Sato, Kaori, Nimptsch, Katharina, Song, Mingyang, Brand-Miller, Jennie C, Morales-Oyarvide, Vicente, Zoltick, Emilie S, Keum, NaNa, Wolpin, Brian M, Meyerhardt, Jeffrey A, Chan, Andrew T, Willett, Walter C, Stampfer, Meir J, Wu, Kana, Giovannucci, Edward L, Fuchs, Charles S, Ng, Kimmie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625675/
https://www.ncbi.nlm.nih.gov/pubmed/28817837
http://dx.doi.org/10.1038/bjc.2017.272
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author Yuan, Chen
Bao, Ying
Sato, Kaori
Nimptsch, Katharina
Song, Mingyang
Brand-Miller, Jennie C
Morales-Oyarvide, Vicente
Zoltick, Emilie S
Keum, NaNa
Wolpin, Brian M
Meyerhardt, Jeffrey A
Chan, Andrew T
Willett, Walter C
Stampfer, Meir J
Wu, Kana
Giovannucci, Edward L
Fuchs, Charles S
Ng, Kimmie
author_facet Yuan, Chen
Bao, Ying
Sato, Kaori
Nimptsch, Katharina
Song, Mingyang
Brand-Miller, Jennie C
Morales-Oyarvide, Vicente
Zoltick, Emilie S
Keum, NaNa
Wolpin, Brian M
Meyerhardt, Jeffrey A
Chan, Andrew T
Willett, Walter C
Stampfer, Meir J
Wu, Kana
Giovannucci, Edward L
Fuchs, Charles S
Ng, Kimmie
author_sort Yuan, Chen
collection PubMed
description BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival. METHODS: We examined the association of post-diagnosis dietary insulin scores with survival among 2006 patients from two large prospective cohorts who were diagnosed with CRC from 1976 to 2010. Dietary insulin load was calculated as a function of the food insulin index. Dietary insulin index was calculated by dividing insulin load by total energy intake. Cox proportional hazards models were used to calculate hazard ratios (HRs) for CRC-specific mortality and overall mortality, adjusted for other risk factors for cancer survival. RESULTS: The adjusted HRs for CRC-specific mortality comparing the highest to the lowest quintiles were 1.82 (95% CI: 1.20–2.75, P(trend)=0.006) for dietary insulin load and 1.66 (95% CI: 1.10–2.50, P(trend)=0.004) for dietary insulin index. We also observed an increased risk for overall mortality, with adjusted HRs of 1.33 (95% CI: 1.03–1.72, P(trend)=0.03) for dietary insulin load and 1.32 (95% CI: 1.02–1.71, P(trend)=0.02) for dietary insulin index, comparing extreme quintiles. The increase in CRC-specific mortality associated with higher dietary insulin scores was more apparent among patients with body mass index (BMI)⩾25 kg m(−2) than BMI<25 kg m(−2) (P(interaction)=0.01). CONCLUSIONS: Higher dietary insulin scores after CRC diagnosis were associated with a statistically significant increase in CRC-specific and overall mortality.
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spelling pubmed-56256752018-09-26 Influence of dietary insulin scores on survival in colorectal cancer patients Yuan, Chen Bao, Ying Sato, Kaori Nimptsch, Katharina Song, Mingyang Brand-Miller, Jennie C Morales-Oyarvide, Vicente Zoltick, Emilie S Keum, NaNa Wolpin, Brian M Meyerhardt, Jeffrey A Chan, Andrew T Willett, Walter C Stampfer, Meir J Wu, Kana Giovannucci, Edward L Fuchs, Charles S Ng, Kimmie Br J Cancer Epidemiology BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival. METHODS: We examined the association of post-diagnosis dietary insulin scores with survival among 2006 patients from two large prospective cohorts who were diagnosed with CRC from 1976 to 2010. Dietary insulin load was calculated as a function of the food insulin index. Dietary insulin index was calculated by dividing insulin load by total energy intake. Cox proportional hazards models were used to calculate hazard ratios (HRs) for CRC-specific mortality and overall mortality, adjusted for other risk factors for cancer survival. RESULTS: The adjusted HRs for CRC-specific mortality comparing the highest to the lowest quintiles were 1.82 (95% CI: 1.20–2.75, P(trend)=0.006) for dietary insulin load and 1.66 (95% CI: 1.10–2.50, P(trend)=0.004) for dietary insulin index. We also observed an increased risk for overall mortality, with adjusted HRs of 1.33 (95% CI: 1.03–1.72, P(trend)=0.03) for dietary insulin load and 1.32 (95% CI: 1.02–1.71, P(trend)=0.02) for dietary insulin index, comparing extreme quintiles. The increase in CRC-specific mortality associated with higher dietary insulin scores was more apparent among patients with body mass index (BMI)⩾25 kg m(−2) than BMI<25 kg m(−2) (P(interaction)=0.01). CONCLUSIONS: Higher dietary insulin scores after CRC diagnosis were associated with a statistically significant increase in CRC-specific and overall mortality. Nature Publishing Group 2017-09-26 2017-08-17 /pmc/articles/PMC5625675/ /pubmed/28817837 http://dx.doi.org/10.1038/bjc.2017.272 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Yuan, Chen
Bao, Ying
Sato, Kaori
Nimptsch, Katharina
Song, Mingyang
Brand-Miller, Jennie C
Morales-Oyarvide, Vicente
Zoltick, Emilie S
Keum, NaNa
Wolpin, Brian M
Meyerhardt, Jeffrey A
Chan, Andrew T
Willett, Walter C
Stampfer, Meir J
Wu, Kana
Giovannucci, Edward L
Fuchs, Charles S
Ng, Kimmie
Influence of dietary insulin scores on survival in colorectal cancer patients
title Influence of dietary insulin scores on survival in colorectal cancer patients
title_full Influence of dietary insulin scores on survival in colorectal cancer patients
title_fullStr Influence of dietary insulin scores on survival in colorectal cancer patients
title_full_unstemmed Influence of dietary insulin scores on survival in colorectal cancer patients
title_short Influence of dietary insulin scores on survival in colorectal cancer patients
title_sort influence of dietary insulin scores on survival in colorectal cancer patients
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625675/
https://www.ncbi.nlm.nih.gov/pubmed/28817837
http://dx.doi.org/10.1038/bjc.2017.272
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