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Human evolution: the non-coding revolution
What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of human accelerated regions (HARs) and other human-specific genome sequences. The major challeng...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625771/ https://www.ncbi.nlm.nih.gov/pubmed/28969617 http://dx.doi.org/10.1186/s12915-017-0428-9 |
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| author | Franchini, Lucía F. Pollard, Katherine S. |
| author_facet | Franchini, Lucía F. Pollard, Katherine S. |
| author_sort | Franchini, Lucía F. |
| collection | PubMed |
| description | What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of human accelerated regions (HARs) and other human-specific genome sequences. The major challenge in the past decade has been to link diverged sequences to uniquely human biology. This review discusses approaches to this problem, progress made at the molecular level, and prospects for moving towards genetic causes for uniquely human biology. |
| format | Online Article Text |
| id | pubmed-5625771 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56257712017-10-12 Human evolution: the non-coding revolution Franchini, Lucía F. Pollard, Katherine S. BMC Biol Review What made us human? Gene expression changes clearly played a significant part in human evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics enabled the identification of human accelerated regions (HARs) and other human-specific genome sequences. The major challenge in the past decade has been to link diverged sequences to uniquely human biology. This review discusses approaches to this problem, progress made at the molecular level, and prospects for moving towards genetic causes for uniquely human biology. BioMed Central 2017-10-02 /pmc/articles/PMC5625771/ /pubmed/28969617 http://dx.doi.org/10.1186/s12915-017-0428-9 Text en © Pollard et al. 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Franchini, Lucía F. Pollard, Katherine S. Human evolution: the non-coding revolution |
| title | Human evolution: the non-coding revolution |
| title_full | Human evolution: the non-coding revolution |
| title_fullStr | Human evolution: the non-coding revolution |
| title_full_unstemmed | Human evolution: the non-coding revolution |
| title_short | Human evolution: the non-coding revolution |
| title_sort | human evolution: the non-coding revolution |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625771/ https://www.ncbi.nlm.nih.gov/pubmed/28969617 http://dx.doi.org/10.1186/s12915-017-0428-9 |
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