Cargando…

Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγ

Type 2 diabetes mellitus is often treated with insulin-sensitizing drugs called thiazolidinediones (TZD), which improve insulin resistance and glycemic control. Despite their effectiveness in treating diabetes, these drugs provide little protection from eminent cardiovascular disease associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, De-Si, Wang, Wei, Liu, Nan-Song, Yang, Qian-Jiao, Zhang, Kun, Zhu, Jing-Zhong, Shan, Song, Li, Zhi-Bin, Ning, Zhi-Qiang, Huang, Laiqiang, Lu, Xian-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625810/ https://www.ncbi.nlm.nih.gov/pubmed/29056962 http://dx.doi.org/10.1155/2017/4313561

Ejemplares similares

In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist
por: He, B. K., et al.
Publicado: (2012)

Personalized glucose-lowering effect of chiglitazar in type 2 diabetes
por: Huang, Qi, et al.
Publicado: (2023)

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex
por: Lemkul, Justin A., et al.
Publicado: (2015)

Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes: A meta-analysis
por: Lin, Chu, et al.
Publicado: (2023)

Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands
por: Choi, Jang Hyun, et al.
Publicado: (2010)

PPARγ S273 Phosphorylation Modifies the Dynamics of Coregulator Proteins Recruitment
por: Dias, Marieli Mariano Gonçalves, et al.
Publicado: (2020)

Comparative Evaluation of Chiglitazar and Sitagliptin on the Levels of Retinol-Binding Protein 4 and Its Correlation With Insulin Resistance in Patients With Type 2 Diabetes
por: Zhou, Yunting, et al.
Publicado: (2022)

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
por: Capelli, Davide, et al.
Publicado: (2023)

The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes
por: Frkic, Rebecca L., et al.
Publicado: (2021)

To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations
por: Sullivan, Holli-Joi, et al.
Publicado: (2020)

Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis
por: Zheng, Qian-Wen, et al.
Publicado: (2021)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions
por: Yang, Nanfei, et al.
Publicado: (2022)

PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
por: Gu, Shu-Jun, et al.
Publicado: (2014)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation
por: Jang, Jun Young, et al.
Publicado: (2019)

Ups and downs: The PPARγ/p-PPARγ seesaw of follistatin-like 1 and integrin receptor signaling in adipogenesis
por: Fang, Dongliang, et al.
Publicado: (2021)

3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
por: Zhang, Yudian, et al.
Publicado: (2023)

Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction
por: Duszka, Kalina, et al.
Publicado: (2016)

Effects of FTO and PPARγ variants on intrauterine growth restriction in a Brazilian birth cohort
por: Barbieri, M.R., et al.
Publicado: (2021)

PPARγ and Apoptosis in Cancer
por: Elrod, Heath A., et al.
Publicado: (2008)

PPARγ, neuroinflammation, and disease
por: Mrak, Robert E, et al.
Publicado: (2004)

Nutraceuticals as Ligands of PPARγ
por: Penumetcha, Meera, et al.
Publicado: (2012)

PPARγ and Cognitive Performance
por: d’Angelo, Michele, et al.
Publicado: (2019)

Baicalin Promotes CNS Remyelination via PPARγ Signal Pathway
por: Ai, Ruo-Song, et al.
Publicado: (2022)

Adropin attenuates pancreatitis-associated lung injury through PPARγ phosphorylation-related macrophage polarization
por: Ding, Fadian, et al.
Publicado: (2023)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation
por: Sun, Leilei, et al.
Publicado: (2023)

A glimpse of the connection between PPARγ and macrophage
por: Yu, Lexiang, et al.
Publicado: (2023)

Serum PPARγ level and PPARγ gene polymorphism as well as severity and prognosis of brain injury in patients with arteriosclotic cerebral infarction
por: Wei, Weiming, et al.
Publicado: (2018)

PPARγ Regulates Triclosan Induced Placental Dysfunction
por: Li, Jing, et al.
Publicado: (2021)

Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS
por: Zhao, Zhigang, et al.
Publicado: (2011)

Haplotype Analysis of PPARγ Gene Polymorphisms and the Lipoprotein (a) Level
por: SHEN, Chao, et al.
Publicado: (2018)

Inhibition of PPARγ during rat pregnancy causes intrauterine growth restriction and attenuation of uterine vasodilation
por: Gokina, Natalia I., et al.
Publicado: (2013)

PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease
por: Song, Yongyan, et al.
Publicado: (2022)

Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes
por: Rogue, Alexandra, et al.
Publicado: (2011)

Enterotoxigenic Escherichia coli Interferes FATP4-Dependent Long-Chain Fatty Acid Uptake of Intestinal Epithelial Enterocytes via Phosphorylation of ERK1/2-PPARγ Pathway
por: Li, Zhi, et al.
Publicado: (2019)

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
por: Xie, Xinni, et al.
Publicado: (2017)

Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation
por: Choi, Jang Hyun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_fhoreo47g199g50ob02b54oi0g