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Flex-nucleoside analogues – Novel therapeutics against filoviruses
Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626011/ https://www.ncbi.nlm.nih.gov/pubmed/28465098 http://dx.doi.org/10.1016/j.bmcl.2017.04.069 |
Sumario: | Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC(50) = 2 μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC(50) of 7 μM. |
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