Flex-nucleoside analogues – Novel therapeutics against filoviruses

Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cel...

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Autores principales: Yates, Mary K., Raje, Mithun R., Chatterjee, Payel, Spiropoulou, Christina F., Bavari, Sina, Flint, Mike, Soloveva, Veronica, Seley-Radtke, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626011/
https://www.ncbi.nlm.nih.gov/pubmed/28465098
http://dx.doi.org/10.1016/j.bmcl.2017.04.069
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author Yates, Mary K.
Raje, Mithun R.
Chatterjee, Payel
Spiropoulou, Christina F.
Bavari, Sina
Flint, Mike
Soloveva, Veronica
Seley-Radtke, Katherine L.
author_facet Yates, Mary K.
Raje, Mithun R.
Chatterjee, Payel
Spiropoulou, Christina F.
Bavari, Sina
Flint, Mike
Soloveva, Veronica
Seley-Radtke, Katherine L.
author_sort Yates, Mary K.
collection PubMed
description Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC(50) = 2 μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC(50) of 7 μM.
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spelling pubmed-56260112018-06-15 Flex-nucleoside analogues – Novel therapeutics against filoviruses Yates, Mary K. Raje, Mithun R. Chatterjee, Payel Spiropoulou, Christina F. Bavari, Sina Flint, Mike Soloveva, Veronica Seley-Radtke, Katherine L. Bioorg Med Chem Lett Article Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC(50) = 2 μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC(50) of 7 μM. Elsevier Ltd. 2017-06-15 2017-04-22 /pmc/articles/PMC5626011/ /pubmed/28465098 http://dx.doi.org/10.1016/j.bmcl.2017.04.069 Text en © 2017 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yates, Mary K.
Raje, Mithun R.
Chatterjee, Payel
Spiropoulou, Christina F.
Bavari, Sina
Flint, Mike
Soloveva, Veronica
Seley-Radtke, Katherine L.
Flex-nucleoside analogues – Novel therapeutics against filoviruses
title Flex-nucleoside analogues – Novel therapeutics against filoviruses
title_full Flex-nucleoside analogues – Novel therapeutics against filoviruses
title_fullStr Flex-nucleoside analogues – Novel therapeutics against filoviruses
title_full_unstemmed Flex-nucleoside analogues – Novel therapeutics against filoviruses
title_short Flex-nucleoside analogues – Novel therapeutics against filoviruses
title_sort flex-nucleoside analogues – novel therapeutics against filoviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626011/
https://www.ncbi.nlm.nih.gov/pubmed/28465098
http://dx.doi.org/10.1016/j.bmcl.2017.04.069
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