Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase. It is considered a potential therapeutic target for the treatment of tuberculosis,...

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Detalles Bibliográficos
Autores principales: Theron, A., Roth, R. L., Hoppe, H., Parkinson, C., van der Westhuyzen, C. W., Stoychev, S., Wiid, I., Pietersen, R. D., Baker, B., Kenyon, C. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626031/
https://www.ncbi.nlm.nih.gov/pubmed/28972974
http://dx.doi.org/10.1371/journal.pone.0185068

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