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Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery

BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; e...

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Autores principales: Jin, Lian-jin, Wen, Li-yong, Zhang, Yan-li, Li, Gang, Sun, Ping, Zhou, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626274/
https://www.ncbi.nlm.nih.gov/pubmed/28953631
http://dx.doi.org/10.1097/MD.0000000000008107
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author Jin, Lian-jin
Wen, Li-yong
Zhang, Yan-li
Li, Gang
Sun, Ping
Zhou, Xuan
author_facet Jin, Lian-jin
Wen, Li-yong
Zhang, Yan-li
Li, Gang
Sun, Ping
Zhou, Xuan
author_sort Jin, Lian-jin
collection PubMed
description BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; each group contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. In addition, subjects in the intervention group also received an additional 1 μg/kg dexmedetomidine. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pain intensity (measured by visual analogue scale, VAS), and analgesic consumption were assessed; adverse events were also recorded. RESULTS: Significant differences were observed in HR (P < .05), SBP (P < .05), and DBP (P < .05) at the 30-minute point during surgery between the 2 groups. In addition, the time of the first administration of analgesia (P = .043) and the mean consumption of analgesic agents (P = .035) in the intervention group were much better than those in the control group. However, no significant differences in HR or VAS were found at any time point after surgery (P > .05). Furthermore, similar adverse events were detected in both groups (P > .05). CONCLUSION: The results of this study showed that TPVBRA combined with bupivacaine and dexmedetomidine can enhance the duration and quality of analgesia without serious adverse events.
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spelling pubmed-56262742017-10-11 Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery Jin, Lian-jin Wen, Li-yong Zhang, Yan-li Li, Gang Sun, Ping Zhou, Xuan Medicine (Baltimore) 5600 BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; each group contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. In addition, subjects in the intervention group also received an additional 1 μg/kg dexmedetomidine. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pain intensity (measured by visual analogue scale, VAS), and analgesic consumption were assessed; adverse events were also recorded. RESULTS: Significant differences were observed in HR (P < .05), SBP (P < .05), and DBP (P < .05) at the 30-minute point during surgery between the 2 groups. In addition, the time of the first administration of analgesia (P = .043) and the mean consumption of analgesic agents (P = .035) in the intervention group were much better than those in the control group. However, no significant differences in HR or VAS were found at any time point after surgery (P > .05). Furthermore, similar adverse events were detected in both groups (P > .05). CONCLUSION: The results of this study showed that TPVBRA combined with bupivacaine and dexmedetomidine can enhance the duration and quality of analgesia without serious adverse events. Wolters Kluwer Health 2017-09-29 /pmc/articles/PMC5626274/ /pubmed/28953631 http://dx.doi.org/10.1097/MD.0000000000008107 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5600
Jin, Lian-jin
Wen, Li-yong
Zhang, Yan-li
Li, Gang
Sun, Ping
Zhou, Xuan
Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title_full Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title_fullStr Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title_full_unstemmed Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title_short Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
title_sort thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626274/
https://www.ncbi.nlm.nih.gov/pubmed/28953631
http://dx.doi.org/10.1097/MD.0000000000008107
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