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Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery
BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626274/ https://www.ncbi.nlm.nih.gov/pubmed/28953631 http://dx.doi.org/10.1097/MD.0000000000008107 |
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author | Jin, Lian-jin Wen, Li-yong Zhang, Yan-li Li, Gang Sun, Ping Zhou, Xuan |
author_facet | Jin, Lian-jin Wen, Li-yong Zhang, Yan-li Li, Gang Sun, Ping Zhou, Xuan |
author_sort | Jin, Lian-jin |
collection | PubMed |
description | BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; each group contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. In addition, subjects in the intervention group also received an additional 1 μg/kg dexmedetomidine. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pain intensity (measured by visual analogue scale, VAS), and analgesic consumption were assessed; adverse events were also recorded. RESULTS: Significant differences were observed in HR (P < .05), SBP (P < .05), and DBP (P < .05) at the 30-minute point during surgery between the 2 groups. In addition, the time of the first administration of analgesia (P = .043) and the mean consumption of analgesic agents (P = .035) in the intervention group were much better than those in the control group. However, no significant differences in HR or VAS were found at any time point after surgery (P > .05). Furthermore, similar adverse events were detected in both groups (P > .05). CONCLUSION: The results of this study showed that TPVBRA combined with bupivacaine and dexmedetomidine can enhance the duration and quality of analgesia without serious adverse events. |
format | Online Article Text |
id | pubmed-5626274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-56262742017-10-11 Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery Jin, Lian-jin Wen, Li-yong Zhang, Yan-li Li, Gang Sun, Ping Zhou, Xuan Medicine (Baltimore) 5600 BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; each group contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. In addition, subjects in the intervention group also received an additional 1 μg/kg dexmedetomidine. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pain intensity (measured by visual analogue scale, VAS), and analgesic consumption were assessed; adverse events were also recorded. RESULTS: Significant differences were observed in HR (P < .05), SBP (P < .05), and DBP (P < .05) at the 30-minute point during surgery between the 2 groups. In addition, the time of the first administration of analgesia (P = .043) and the mean consumption of analgesic agents (P = .035) in the intervention group were much better than those in the control group. However, no significant differences in HR or VAS were found at any time point after surgery (P > .05). Furthermore, similar adverse events were detected in both groups (P > .05). CONCLUSION: The results of this study showed that TPVBRA combined with bupivacaine and dexmedetomidine can enhance the duration and quality of analgesia without serious adverse events. Wolters Kluwer Health 2017-09-29 /pmc/articles/PMC5626274/ /pubmed/28953631 http://dx.doi.org/10.1097/MD.0000000000008107 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5600 Jin, Lian-jin Wen, Li-yong Zhang, Yan-li Li, Gang Sun, Ping Zhou, Xuan Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title | Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title_full | Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title_fullStr | Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title_full_unstemmed | Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title_short | Thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
title_sort | thoracic paravertebral regional anesthesia for pain relief in patients with breast cancer surgery |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626274/ https://www.ncbi.nlm.nih.gov/pubmed/28953631 http://dx.doi.org/10.1097/MD.0000000000008107 |
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