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SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients

Nav1.9, encoded by sodium voltage-gated channel alpha subunit 11 (SCN11A), is one of the main sodium channels involved in pain transmission. Dysfunction of Nav1.9 alters pain sensitivity, resulting in insensitivity to pain or familial episodic pain. Our purpose was to explore the effects of SCN11A s...

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Autores principales: Sun, Jiaoli, Duan, Guangyou, Li, Ningbo, Guo, Shanna, Zhang, Yuhao, Ying, Ying, Zhang, Mi, Wang, Qingli, Liu, Jing Yu, Zhang, Xianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626299/
https://www.ncbi.nlm.nih.gov/pubmed/28953656
http://dx.doi.org/10.1097/MD.0000000000008149
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author Sun, Jiaoli
Duan, Guangyou
Li, Ningbo
Guo, Shanna
Zhang, Yuhao
Ying, Ying
Zhang, Mi
Wang, Qingli
Liu, Jing Yu
Zhang, Xianwei
author_facet Sun, Jiaoli
Duan, Guangyou
Li, Ningbo
Guo, Shanna
Zhang, Yuhao
Ying, Ying
Zhang, Mi
Wang, Qingli
Liu, Jing Yu
Zhang, Xianwei
author_sort Sun, Jiaoli
collection PubMed
description Nav1.9, encoded by sodium voltage-gated channel alpha subunit 11 (SCN11A), is one of the main sodium channels involved in pain transmission. Dysfunction of Nav1.9 alters pain sensitivity, resulting in insensitivity to pain or familial episodic pain. Our purpose was to explore the effects of SCN11A single-nucleotide polymorphisms (SNPs) on postoperative pain sensitivity in Chinese Han female patients after gynecological surgery. Here, we combined the methods of tag SNPs and candidate SNPs. The associations between eleven SCN11A SNPs and basic pain sensitivity in female healthy volunteers were analyzed using the Plink software. The SNPs associated with basic pain sensitivity were termed positive SCN11A SNPs. The effect of these positive SNPs on postoperative pain sensitivity was explored in patients undergoing elective gynecological laparoscopic surgery and receiving postoperative patient-controlled analgesia (PCA). We assessed pain intensity using the numeric pain rating scale (NRS) and recorded PCA consumption. Our results suggested that 5 SNPs (rs33985936, rs13080116, rs11720988, rs11709492, and rs11720013) in 11 tag and candidate SNPs were associated with basic pain sensitivity (P < .05). No evident association was found between the 5 positive SNPs and NRS (P > .05). However, among these positive SNPs, the minor alleles of rs33985936 and rs13080116 were significantly associated with increased PCA consumption (P < .01). To our knowledge, this is the first study to report that SCN11A SNPs affect postoperative pain sensitivity in Chinese Han women after gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for postoperative pain.
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spelling pubmed-56262992017-10-11 SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients Sun, Jiaoli Duan, Guangyou Li, Ningbo Guo, Shanna Zhang, Yuhao Ying, Ying Zhang, Mi Wang, Qingli Liu, Jing Yu Zhang, Xianwei Medicine (Baltimore) 3300 Nav1.9, encoded by sodium voltage-gated channel alpha subunit 11 (SCN11A), is one of the main sodium channels involved in pain transmission. Dysfunction of Nav1.9 alters pain sensitivity, resulting in insensitivity to pain or familial episodic pain. Our purpose was to explore the effects of SCN11A single-nucleotide polymorphisms (SNPs) on postoperative pain sensitivity in Chinese Han female patients after gynecological surgery. Here, we combined the methods of tag SNPs and candidate SNPs. The associations between eleven SCN11A SNPs and basic pain sensitivity in female healthy volunteers were analyzed using the Plink software. The SNPs associated with basic pain sensitivity were termed positive SCN11A SNPs. The effect of these positive SNPs on postoperative pain sensitivity was explored in patients undergoing elective gynecological laparoscopic surgery and receiving postoperative patient-controlled analgesia (PCA). We assessed pain intensity using the numeric pain rating scale (NRS) and recorded PCA consumption. Our results suggested that 5 SNPs (rs33985936, rs13080116, rs11720988, rs11709492, and rs11720013) in 11 tag and candidate SNPs were associated with basic pain sensitivity (P < .05). No evident association was found between the 5 positive SNPs and NRS (P > .05). However, among these positive SNPs, the minor alleles of rs33985936 and rs13080116 were significantly associated with increased PCA consumption (P < .01). To our knowledge, this is the first study to report that SCN11A SNPs affect postoperative pain sensitivity in Chinese Han women after gynecological surgery. The SNP rs33985936 and rs13080116 may serve as novel predictors for postoperative pain. Wolters Kluwer Health 2017-09-29 /pmc/articles/PMC5626299/ /pubmed/28953656 http://dx.doi.org/10.1097/MD.0000000000008149 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 3300
Sun, Jiaoli
Duan, Guangyou
Li, Ningbo
Guo, Shanna
Zhang, Yuhao
Ying, Ying
Zhang, Mi
Wang, Qingli
Liu, Jing Yu
Zhang, Xianwei
SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title_full SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title_fullStr SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title_full_unstemmed SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title_short SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients
title_sort scn11a variants may influence postoperative pain sensitivity after gynecological surgery in chinese han female patients
topic 3300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626299/
https://www.ncbi.nlm.nih.gov/pubmed/28953656
http://dx.doi.org/10.1097/MD.0000000000008149
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