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Molecular classification of esophagogastric junction carcinoma correlated with prognosis
A novel molecular classification of gastric cancer by the Asian Cancer Research Group (ACRG) is a potential advance in diagnosis and treatment, and it helps to determine prognosis. The use of immunohistochemistry (IHC) rather than gene expression analysis to determine tumor subtypes was evaluated wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626374/ https://www.ncbi.nlm.nih.gov/pubmed/29026322 http://dx.doi.org/10.2147/OTT.S145912 |
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author | Zou, Long Wu, Yinying Ma, Ke Fan, Yangwei Dong, Danfeng Geng, Ningyan Li, Enxiao |
author_facet | Zou, Long Wu, Yinying Ma, Ke Fan, Yangwei Dong, Danfeng Geng, Ningyan Li, Enxiao |
author_sort | Zou, Long |
collection | PubMed |
description | A novel molecular classification of gastric cancer by the Asian Cancer Research Group (ACRG) is a potential advance in diagnosis and treatment, and it helps to determine prognosis. The use of immunohistochemistry (IHC) rather than gene expression analysis to determine tumor subtypes was evaluated with the aim of determining the feasibility of using the ACRG molecular classification. A total of 69 esophagogastric junction (EGJ) carcinomas were classified as microsatellite instable (MSI, 17.40%, 12 of 69), microsatellite stable with markers of epithelial-to-mesenchymal transition (MSS/EMT, 18.84%, 13 of 69), microsatellite stable with active tumor protein 53 (MSS/TP53(+), 27.53%, 19 of 69), and microsatellite stable with inactive TP53 (MSS/TP53(−), 36.23%, 25 of 69). The molecular classification did not significantly correlate with anyone of the clinicopathological characteristics of the EGJ carcinoma patients, including age, gender, depth of tumor invasion, the presence of lymph node metastasis, histologic grade, and p-TNM stage of the American Joint Committee on Cancer (P>0.05). Kaplan–Meier survival analysis and log rank tests showed that molecular classification, histologic grade, p-TNM stage, and postoperative adjuvant chemotherapy were significantly associated with overall survival (OS; P<0.05). MSI tumors had the best overall prognosis followed by MSS/TP53(−) and MSS/TP53(+). MSS/EMT tumors had the worst overall prognosis. Multivariate analysis revealed that histologic grade (hazard ratio [HR] =2.216, 95% CI =1.202–4.086), p-TNM stage (HR =2.216, 95% CI =1.202–4.086), and molecular subtype (HR =2.216, 95% CI =1.202–4.086) were independently associated with OS. The preliminary results suggested that the ACRG molecular classification may be a valuable independent prognostic marker for EGJ carcinoma patients and could be performed by IHC analysis. |
format | Online Article Text |
id | pubmed-5626374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56263742017-10-12 Molecular classification of esophagogastric junction carcinoma correlated with prognosis Zou, Long Wu, Yinying Ma, Ke Fan, Yangwei Dong, Danfeng Geng, Ningyan Li, Enxiao Onco Targets Ther Original Research A novel molecular classification of gastric cancer by the Asian Cancer Research Group (ACRG) is a potential advance in diagnosis and treatment, and it helps to determine prognosis. The use of immunohistochemistry (IHC) rather than gene expression analysis to determine tumor subtypes was evaluated with the aim of determining the feasibility of using the ACRG molecular classification. A total of 69 esophagogastric junction (EGJ) carcinomas were classified as microsatellite instable (MSI, 17.40%, 12 of 69), microsatellite stable with markers of epithelial-to-mesenchymal transition (MSS/EMT, 18.84%, 13 of 69), microsatellite stable with active tumor protein 53 (MSS/TP53(+), 27.53%, 19 of 69), and microsatellite stable with inactive TP53 (MSS/TP53(−), 36.23%, 25 of 69). The molecular classification did not significantly correlate with anyone of the clinicopathological characteristics of the EGJ carcinoma patients, including age, gender, depth of tumor invasion, the presence of lymph node metastasis, histologic grade, and p-TNM stage of the American Joint Committee on Cancer (P>0.05). Kaplan–Meier survival analysis and log rank tests showed that molecular classification, histologic grade, p-TNM stage, and postoperative adjuvant chemotherapy were significantly associated with overall survival (OS; P<0.05). MSI tumors had the best overall prognosis followed by MSS/TP53(−) and MSS/TP53(+). MSS/EMT tumors had the worst overall prognosis. Multivariate analysis revealed that histologic grade (hazard ratio [HR] =2.216, 95% CI =1.202–4.086), p-TNM stage (HR =2.216, 95% CI =1.202–4.086), and molecular subtype (HR =2.216, 95% CI =1.202–4.086) were independently associated with OS. The preliminary results suggested that the ACRG molecular classification may be a valuable independent prognostic marker for EGJ carcinoma patients and could be performed by IHC analysis. Dove Medical Press 2017-09-25 /pmc/articles/PMC5626374/ /pubmed/29026322 http://dx.doi.org/10.2147/OTT.S145912 Text en © 2017 Zou et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zou, Long Wu, Yinying Ma, Ke Fan, Yangwei Dong, Danfeng Geng, Ningyan Li, Enxiao Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title | Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title_full | Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title_fullStr | Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title_full_unstemmed | Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title_short | Molecular classification of esophagogastric junction carcinoma correlated with prognosis |
title_sort | molecular classification of esophagogastric junction carcinoma correlated with prognosis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626374/ https://www.ncbi.nlm.nih.gov/pubmed/29026322 http://dx.doi.org/10.2147/OTT.S145912 |
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