NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome

Although B cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact for most B cells. Here, we show that BCR engagement by self-ligand during development in vivo results in up-regulation of the Nod-lik...

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Detalles Bibliográficos
Autores principales: Hayakawa, Kyoko, Formica, Anthony M., Zhou, Yan, Ichikawa, Daiju, Asano, Masanao, Li, Yue-Sheng, Shinton, Susan A., Brill-Dashoff, Joni, Núñez, Gabriel, Hardy, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626402/
https://www.ncbi.nlm.nih.gov/pubmed/28878001
http://dx.doi.org/10.1084/jem.20170497

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