Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis

Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete...

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Detalles Bibliográficos
Autores principales: Perlin, Julie R., Robertson, Anne L., Zon, Leonard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626407/
https://www.ncbi.nlm.nih.gov/pubmed/28830909
http://dx.doi.org/10.1084/jem.20171069
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author Perlin, Julie R.
Robertson, Anne L.
Zon, Leonard I.
author_facet Perlin, Julie R.
Robertson, Anne L.
Zon, Leonard I.
author_sort Perlin, Julie R.
collection PubMed
description Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. Recent studies in zebrafish have revealed novel genes that are required for HSC induction and niche regulation of HSC homeostasis. Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies.
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spelling pubmed-56264072018-04-02 Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis Perlin, Julie R. Robertson, Anne L. Zon, Leonard I. J Exp Med Reviews Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro. There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. Recent studies in zebrafish have revealed novel genes that are required for HSC induction and niche regulation of HSC homeostasis. Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies. The Rockefeller University Press 2017-10-02 /pmc/articles/PMC5626407/ /pubmed/28830909 http://dx.doi.org/10.1084/jem.20171069 Text en © 2017 Perlin et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Perlin, Julie R.
Robertson, Anne L.
Zon, Leonard I.
Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title_full Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title_fullStr Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title_full_unstemmed Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title_short Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
title_sort efforts to enhance blood stem cell engraftment: recent insights from zebrafish hematopoiesis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626407/
https://www.ncbi.nlm.nih.gov/pubmed/28830909
http://dx.doi.org/10.1084/jem.20171069
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AT zonleonardi effortstoenhancebloodstemcellengraftmentrecentinsightsfromzebrafishhematopoiesis

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