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Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma

PURPOSE: To identify sectors of the optical coherence tomography (OCT) macular map that could be used to effectively assess structural progression in patients with normal-tension glaucoma (NTG). METHODS: This study examined 117 eyes of 117 NTG patients to establish axonal tract-dependent macular sec...

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Autores principales: Omodaka, Kazuko, Kikawa, Tsutomu, Shiga, Yukihiro, Tsuda, Satoru, Yokoyama, Yu, Sato, Haruka, Ohuchi, Junko, Matsumoto, Akiko, Takahashi, Hidetoshi, Akiba, Masahiro, Nakazawa, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626427/
https://www.ncbi.nlm.nih.gov/pubmed/28973002
http://dx.doi.org/10.1371/journal.pone.0185649
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author Omodaka, Kazuko
Kikawa, Tsutomu
Shiga, Yukihiro
Tsuda, Satoru
Yokoyama, Yu
Sato, Haruka
Ohuchi, Junko
Matsumoto, Akiko
Takahashi, Hidetoshi
Akiba, Masahiro
Nakazawa, Toru
author_facet Omodaka, Kazuko
Kikawa, Tsutomu
Shiga, Yukihiro
Tsuda, Satoru
Yokoyama, Yu
Sato, Haruka
Ohuchi, Junko
Matsumoto, Akiko
Takahashi, Hidetoshi
Akiba, Masahiro
Nakazawa, Toru
author_sort Omodaka, Kazuko
collection PubMed
description PURPOSE: To identify sectors of the optical coherence tomography (OCT) macular map that could be used to effectively assess structural progression in patients with normal-tension glaucoma (NTG). METHODS: This study examined 117 eyes of 117 NTG patients to establish axonal tract-dependent macular sectors, and also examined a separate group of 122 eyes of 81 NTG patients to evaluate the ability of these sectors to reveal glaucoma progression. Longitudinal data, including macular maps from at least 5 OCT examinations performed over at least 2 years, was available for all patients in this group. Circumpapillary retinal nerve fiber layer thickness (cpRNFLT), temporal clockwise sector scans (from 7 to 11 o’clock), macular retinal nerve fiber layer thickness (mRNFLT), and macular ganglion cell layer plus inner plexiform layer thickness (mGCIPLT) were measured with spectral-domain OCT (3D OCT-2000, TOPCON). The axonal tract-dependent macular sectors were identified by calculating Spearman’s rank correlation coefficient for each point on a grid overlaid on the macular map and cpRNFLT in each clockwise scan sector. Trend and event analyses for the slope of progression in each sector and macular map were performed. Visual field progression in the macula was defined by the presence of more than 2 progressive test points in the 16 central test points of the Humphrey field analyzer SITA standard 24–2 program, evaluated with Progressor software. RESULTS: The slope of progression in the entire macular area was -0.22 ± 0.58 μm/year for mRNFLT and -0.35 ± 0.52 μm/year for mGCIPLT. The fastest-progressing mRNFLT sector (-1.00 ± 0.84 μm/year, p < 0.001) and mGCIPLT sector (-1.16 ± 0.63 μm/year, p < 0.001) progressed significantly faster than the overall macula. Classifying patients according to visual field progression showed that baseline mRNFLT in the inferior hemifield, 7 and 8 o’clock sectors, as well as baseline mGCIPLT in the overall macular map, inferior hemifield, and 8 o’clock sector, were significantly lower in progressors (22 eyes) than non-progressors (100 eyes). There were significant differences in mRNFLT slope in 8 o’clock sector and in the fastest progressing sector in progressors and non-progressors, but mGCIPLT did not differ, even in the fastest-progressing sector. Event analysis showed that progression occurred most frequently in inferior mRNFLT and superior mGCIPLT in this study. CONCLUSION: Axonal tract-dependent OCT macular sectors could effectively reveal structural change in patients with NTG. Furthermore, mRNFLT slope was consistent with visual field progression. This method promises to open new avenues for the OCT-based evaluation of glaucoma progression.
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spelling pubmed-56264272017-10-17 Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma Omodaka, Kazuko Kikawa, Tsutomu Shiga, Yukihiro Tsuda, Satoru Yokoyama, Yu Sato, Haruka Ohuchi, Junko Matsumoto, Akiko Takahashi, Hidetoshi Akiba, Masahiro Nakazawa, Toru PLoS One Research Article PURPOSE: To identify sectors of the optical coherence tomography (OCT) macular map that could be used to effectively assess structural progression in patients with normal-tension glaucoma (NTG). METHODS: This study examined 117 eyes of 117 NTG patients to establish axonal tract-dependent macular sectors, and also examined a separate group of 122 eyes of 81 NTG patients to evaluate the ability of these sectors to reveal glaucoma progression. Longitudinal data, including macular maps from at least 5 OCT examinations performed over at least 2 years, was available for all patients in this group. Circumpapillary retinal nerve fiber layer thickness (cpRNFLT), temporal clockwise sector scans (from 7 to 11 o’clock), macular retinal nerve fiber layer thickness (mRNFLT), and macular ganglion cell layer plus inner plexiform layer thickness (mGCIPLT) were measured with spectral-domain OCT (3D OCT-2000, TOPCON). The axonal tract-dependent macular sectors were identified by calculating Spearman’s rank correlation coefficient for each point on a grid overlaid on the macular map and cpRNFLT in each clockwise scan sector. Trend and event analyses for the slope of progression in each sector and macular map were performed. Visual field progression in the macula was defined by the presence of more than 2 progressive test points in the 16 central test points of the Humphrey field analyzer SITA standard 24–2 program, evaluated with Progressor software. RESULTS: The slope of progression in the entire macular area was -0.22 ± 0.58 μm/year for mRNFLT and -0.35 ± 0.52 μm/year for mGCIPLT. The fastest-progressing mRNFLT sector (-1.00 ± 0.84 μm/year, p < 0.001) and mGCIPLT sector (-1.16 ± 0.63 μm/year, p < 0.001) progressed significantly faster than the overall macula. Classifying patients according to visual field progression showed that baseline mRNFLT in the inferior hemifield, 7 and 8 o’clock sectors, as well as baseline mGCIPLT in the overall macular map, inferior hemifield, and 8 o’clock sector, were significantly lower in progressors (22 eyes) than non-progressors (100 eyes). There were significant differences in mRNFLT slope in 8 o’clock sector and in the fastest progressing sector in progressors and non-progressors, but mGCIPLT did not differ, even in the fastest-progressing sector. Event analysis showed that progression occurred most frequently in inferior mRNFLT and superior mGCIPLT in this study. CONCLUSION: Axonal tract-dependent OCT macular sectors could effectively reveal structural change in patients with NTG. Furthermore, mRNFLT slope was consistent with visual field progression. This method promises to open new avenues for the OCT-based evaluation of glaucoma progression. Public Library of Science 2017-10-03 /pmc/articles/PMC5626427/ /pubmed/28973002 http://dx.doi.org/10.1371/journal.pone.0185649 Text en © 2017 Omodaka et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Omodaka, Kazuko
Kikawa, Tsutomu
Shiga, Yukihiro
Tsuda, Satoru
Yokoyama, Yu
Sato, Haruka
Ohuchi, Junko
Matsumoto, Akiko
Takahashi, Hidetoshi
Akiba, Masahiro
Nakazawa, Toru
Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title_full Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title_fullStr Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title_full_unstemmed Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title_short Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma
title_sort usefulness of axonal tract-dependent oct macular sectors for evaluating structural change in normal-tension glaucoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626427/
https://www.ncbi.nlm.nih.gov/pubmed/28973002
http://dx.doi.org/10.1371/journal.pone.0185649
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