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Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range

Neuronal inhibition is crucial for temporally precise and reproducible signaling in the auditory brainstem. Previously we showed that for various synthetic stimuli, spherical bushy cell (SBC) activity in the Mongolian gerbil is rendered sparser and more reliable by subtractive inhibition (Keine et a...

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Autores principales: Keine, Christian, Rübsamen, Rudolf, Englitz, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626481/
https://www.ncbi.nlm.nih.gov/pubmed/28945194
http://dx.doi.org/10.7554/eLife.29639
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author Keine, Christian
Rübsamen, Rudolf
Englitz, Bernhard
author_facet Keine, Christian
Rübsamen, Rudolf
Englitz, Bernhard
author_sort Keine, Christian
collection PubMed
description Neuronal inhibition is crucial for temporally precise and reproducible signaling in the auditory brainstem. Previously we showed that for various synthetic stimuli, spherical bushy cell (SBC) activity in the Mongolian gerbil is rendered sparser and more reliable by subtractive inhibition (Keine et al., 2016). Here, employing environmental stimuli, we demonstrate that the inhibitory gain control becomes even more effective, keeping stimulated response rates equal to spontaneous ones. However, what are the costs of this modulation? We performed dynamic stimulus reconstructions based on neural population responses for auditory nerve (ANF) input and SBC output to assess the influence of inhibition on acoustic signal representation. Compared to ANFs, reconstructions of natural stimuli based on SBC responses were temporally more precise, but the match between acoustic and represented signal decreased. Hence, for natural sounds, inhibition at SBCs plays an even stronger role in achieving sparse and reproducible neuronal activity, while compromising general signal representation.
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spelling pubmed-56264812017-10-04 Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range Keine, Christian Rübsamen, Rudolf Englitz, Bernhard eLife Neuroscience Neuronal inhibition is crucial for temporally precise and reproducible signaling in the auditory brainstem. Previously we showed that for various synthetic stimuli, spherical bushy cell (SBC) activity in the Mongolian gerbil is rendered sparser and more reliable by subtractive inhibition (Keine et al., 2016). Here, employing environmental stimuli, we demonstrate that the inhibitory gain control becomes even more effective, keeping stimulated response rates equal to spontaneous ones. However, what are the costs of this modulation? We performed dynamic stimulus reconstructions based on neural population responses for auditory nerve (ANF) input and SBC output to assess the influence of inhibition on acoustic signal representation. Compared to ANFs, reconstructions of natural stimuli based on SBC responses were temporally more precise, but the match between acoustic and represented signal decreased. Hence, for natural sounds, inhibition at SBCs plays an even stronger role in achieving sparse and reproducible neuronal activity, while compromising general signal representation. eLife Sciences Publications, Ltd 2017-09-25 /pmc/articles/PMC5626481/ /pubmed/28945194 http://dx.doi.org/10.7554/eLife.29639 Text en © 2017, Keine et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Keine, Christian
Rübsamen, Rudolf
Englitz, Bernhard
Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title_full Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title_fullStr Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title_full_unstemmed Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title_short Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
title_sort signal integration at spherical bushy cells enhances representation of temporal structure but limits its range
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626481/
https://www.ncbi.nlm.nih.gov/pubmed/28945194
http://dx.doi.org/10.7554/eLife.29639
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