A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein

MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for increased MdmX protein levels in human cancers, i...

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Detalles Bibliográficos
Autores principales: Valianatos, Georgios, Valcikova, Barbora, Growkova, Katerina, Verlande, Amandine, Mlcochova, Jitka, Radova, Lenka, Stetkova, Monika, Vyhnakova, Michaela, Slaby, Ondrej, Uldrijan, Stjepan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626491/
https://www.ncbi.nlm.nih.gov/pubmed/28973015
http://dx.doi.org/10.1371/journal.pone.0185801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626491/
https://www.ncbi.nlm.nih.gov/pubmed/28973015
http://dx.doi.org/10.1371/journal.pone.0185801

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