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Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model

After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic rela...

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Detalles Bibliográficos
Autores principales:	Abla, Nada, Keiser, Jennifer, Vargas, Mireille, Reimers, Natalie, Haas, Helmut, Spangenberg, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626502/ https://www.ncbi.nlm.nih.gov/pubmed/28934207 http://dx.doi.org/10.1371/journal.pntd.0005942

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