A Rab5 GTPase module is important for autophagosome closure

In the conserved autophagy pathway, the double-membrane autophagosome (AP) engulfs cellular components to be delivered for degradation in the lysosome. While only sealed AP can productively fuse with the lysosome, the molecular mechanism of AP closure is currently unknown. Rab GTPases, which regulat...

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Detalles Bibliográficos
Autores principales: Zhou, Fan, Zou, Shenshen, Chen, Yong, Lipatova, Zhanna, Sun, Dan, Zhu, Xiaolong, Li, Rui, Wu, Zulin, You, Weiming, Cong, Xiaoxia, Zhou, Yiting, Xie, Zhiping, Gyurkovska, Valeriya, Liu, Yutao, Li, Qunli, Li, Wenjing, Cheng, Jie, Liang, Yongheng, Segev, Nava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626503/
https://www.ncbi.nlm.nih.gov/pubmed/28934205
http://dx.doi.org/10.1371/journal.pgen.1007020

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