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Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5’-phosphate and 3’-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known as MCSZ, but these individuals are not predisposed fo...

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Detalles Bibliográficos
Autores principales:	Sanchez, Arancha, Gadaleta, Mariana C., Limbo, Oliver, Russell, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626526/ https://www.ncbi.nlm.nih.gov/pubmed/28922417 http://dx.doi.org/10.1371/journal.pgen.1007013

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