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Mitochondrial fission facilitates the selective mitophagy of protein aggregates
Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We explore how autophagy eliminates protein aggregates from within mitochondria and the role of mitochondrial fission in mitophag...
Autores principales: | Burman, Jonathon L., Pickles, Sarah, Wang, Chunxin, Sekine, Shiori, Vargas, Jose Norberto S., Zhang, Zhe, Youle, Alice M., Nezich, Catherine L., Wu, Xufeng, Hammer, John A., Youle, Richard J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626535/ https://www.ncbi.nlm.nih.gov/pubmed/28893839 http://dx.doi.org/10.1083/jcb.201612106 |
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