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DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

The mechanisms by which neoplastic cells tolerate oncogene-induced DNA replication stress are poorly understood. Cyclin-dependent kinase 2 (CDK2) is a major mediator of oncogenic DNA replication stress. In this study, we show that CDK2-inducing stimuli (including Cyclin E overexpression, oncogenic R...

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Detalles Bibliográficos
Autores principales:	Yang, Yang, Gao, Yanzhe, Mutter-Rottmayer, Liz, Zlatanou, Anastasia, Durando, Michael, Ding, Weimin, Wyatt, David, Ramsden, Dale, Tanoue, Yuki, Tateishi, Satoshi, Vaziri, Cyrus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626543/ https://www.ncbi.nlm.nih.gov/pubmed/28835467 http://dx.doi.org/10.1083/jcb.201702006

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