Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking

Shiga toxins 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol. Early endosome-to-Golgi transport allows the toxins to evade degradation in lysosomes. Targeting this trafficking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2 is...

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Detalles Bibliográficos
Autores principales: Selyunin, Andrey S., Iles, Lakesla R., Bartholomeusz, Geoffrey, Mukhopadhyay, Somshuvra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626549/
https://www.ncbi.nlm.nih.gov/pubmed/28883040
http://dx.doi.org/10.1083/jcb.201704015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626549/
https://www.ncbi.nlm.nih.gov/pubmed/28883040
http://dx.doi.org/10.1083/jcb.201704015

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