DNA damage-induced immune response: Micronuclei provide key platform

DNA damage–induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. Nature. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. Nature. http://dx.doi.org/10.1038/nature23449), and Bar...

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Autor principal: Gekara, Nelson O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626557/
https://www.ncbi.nlm.nih.gov/pubmed/28860276
http://dx.doi.org/10.1083/jcb.201708069
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author Gekara, Nelson O.
author_facet Gekara, Nelson O.
author_sort Gekara, Nelson O.
collection PubMed
description DNA damage–induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. Nature. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. Nature. http://dx.doi.org/10.1038/nature23449), and Bartsch et al. (2017. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddx283) demonstrate a role for micronuclei formation in DNA damage–induced immune activation.
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spelling pubmed-56265572018-04-02 DNA damage-induced immune response: Micronuclei provide key platform Gekara, Nelson O. J Cell Biol Commentary DNA damage–induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017. Nature. http://dx.doi.org/10.1038/nature23470), Mackenzie et al. (2017. Nature. http://dx.doi.org/10.1038/nature23449), and Bartsch et al. (2017. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddx283) demonstrate a role for micronuclei formation in DNA damage–induced immune activation. The Rockefeller University Press 2017-10-02 /pmc/articles/PMC5626557/ /pubmed/28860276 http://dx.doi.org/10.1083/jcb.201708069 Text en © 2017 Gekara http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Gekara, Nelson O.
DNA damage-induced immune response: Micronuclei provide key platform
title DNA damage-induced immune response: Micronuclei provide key platform
title_full DNA damage-induced immune response: Micronuclei provide key platform
title_fullStr DNA damage-induced immune response: Micronuclei provide key platform
title_full_unstemmed DNA damage-induced immune response: Micronuclei provide key platform
title_short DNA damage-induced immune response: Micronuclei provide key platform
title_sort dna damage-induced immune response: micronuclei provide key platform
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626557/
https://www.ncbi.nlm.nih.gov/pubmed/28860276
http://dx.doi.org/10.1083/jcb.201708069
work_keys_str_mv AT gekaranelsono dnadamageinducedimmuneresponsemicronucleiprovidekeyplatform

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