A new Rab7 effector controls phosphoinositide conversion in endosome maturation

Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kina...

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Detalles Bibliográficos
Autores principales: Casanova, James E., Winckler, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626559/
https://www.ncbi.nlm.nih.gov/pubmed/28928133
http://dx.doi.org/10.1083/jcb.201709034
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author Casanova, James E.
Winckler, Bettina
author_facet Casanova, James E.
Winckler, Bettina
author_sort Casanova, James E.
collection PubMed
description Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo.
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spelling pubmed-56265592018-04-02 A new Rab7 effector controls phosphoinositide conversion in endosome maturation Casanova, James E. Winckler, Bettina J Cell Biol Commentary Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo. The Rockefeller University Press 2017-10-02 /pmc/articles/PMC5626559/ /pubmed/28928133 http://dx.doi.org/10.1083/jcb.201709034 Text en © 2017 Casanova and Winckler http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Casanova, James E.
Winckler, Bettina
A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title_full A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title_fullStr A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title_full_unstemmed A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title_short A new Rab7 effector controls phosphoinositide conversion in endosome maturation
title_sort new rab7 effector controls phosphoinositide conversion in endosome maturation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626559/
https://www.ncbi.nlm.nih.gov/pubmed/28928133
http://dx.doi.org/10.1083/jcb.201709034
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