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Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging

Although drug distribution in tumor tissues has a significant impact on efficacy, conventional pharmacokinetic analysis has some limitations with regard to its ability to provide a comprehensive assessment of drug tissue distribution. Erlotinib is a tyrosine kinase inhibitor that acts on the epiderm...

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Detalles Bibliográficos
Autores principales:	Tsubata, Yukari, Hayashi, Mitsuhiro, Tanino, Ryosuke, Aikawa, Hiroaki, Ohuchi, Mayu, Tamura, Kenji, Fujiwara, Yasuhiro, Isobe, Takeshi, Hamada, Akinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626687/ https://www.ncbi.nlm.nih.gov/pubmed/28974758 http://dx.doi.org/10.1038/s41598-017-13025-8

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