Age at menarche and prevalence of preterm birth: Results from the Healthy Baby Cohort study

Little is known about the impact of age at menarche on preterm birth. The aim of this study was to examine the association between age at menarche and preterm birth. A total of 11,016 Chinese women who gave birth to live singleton infants were recruited from the Healthy Baby Cohort between 2012 and 2014 in the province of Hubei, China. Age at menarche was reported via face-to-face interviews and was categorized into five groups (≤11, 12, 13, 14 and ≥15 years). Gestational age was estimated using maternal last menstrual period. Preterm birth was defined as delivering a live singleton infant at <37 weeks’ gestational age. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Earlier menarche (≤11 years) was associated with an increased prevalence of preterm birth (OR: 1.67, 95% CI: 1.18, 2.36) compared with menarche age at 13 years after controlling for the potential confounders. The findings of our study suggested that a history of earlier menarche might be useful for identifying women at higher risk of preterm birth.