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Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer’s-model mice

Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine’s buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting...

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Detalles Bibliográficos
Autores principales: Kaneko, Jun, Enya, Akiko, Enomoto, Kota, Ding, Qiong, Hisatsune, Tatsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626714/
https://www.ncbi.nlm.nih.gov/pubmed/28974740
http://dx.doi.org/10.1038/s41598-017-12785-7