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Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study
Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626868/ https://www.ncbi.nlm.nih.gov/pubmed/29033829 http://dx.doi.org/10.3389/fnagi.2017.00318 |
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author | Robertson, Andrew D. Marzolini, Susan Middleton, Laura E. Basile, Vincenzo S. Oh, Paul I. MacIntosh, Bradley J. |
author_facet | Robertson, Andrew D. Marzolini, Susan Middleton, Laura E. Basile, Vincenzo S. Oh, Paul I. MacIntosh, Bradley J. |
author_sort | Robertson, Andrew D. |
collection | PubMed |
description | Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart. In the prospective observational study, eight individuals underwent ASL imaging and aerobic fitness testing before and after a 6-month cardiovascular rehabilitation program. Cerebral blood flow (CBF) and the spatial coefficient of variation of CBF (sCoV) were quantified to characterize tissue-level perfusion and large cerebral artery transit time properties, respectively. In repeat scanning, intraclass correlation (ICC) indicated moderate test-retest reliability for global gray matter CBF (ICC = 0.73) and excellent reliability for sCoV (ICC = 0.94). In the observational study, gray matter CBF increased after training (baseline: 40 ± 13 vs. 6-month: 46 ± 12 ml·100 g(−1)·min(−1), P = 0.036). The greatest change occurred in the parietal lobe (+18 ± 12%). Gray matter sCoV, however, did not change following training (P = 0.31). This study provides preliminary evidence that exercise-based rehabilitation in chronic stroke enhances tissue-level perfusion, without changing the relative hemodynamic properties of the large cerebral arteries. |
format | Online Article Text |
id | pubmed-5626868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56268682017-10-13 Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study Robertson, Andrew D. Marzolini, Susan Middleton, Laura E. Basile, Vincenzo S. Oh, Paul I. MacIntosh, Bradley J. Front Aging Neurosci Neuroscience Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart. In the prospective observational study, eight individuals underwent ASL imaging and aerobic fitness testing before and after a 6-month cardiovascular rehabilitation program. Cerebral blood flow (CBF) and the spatial coefficient of variation of CBF (sCoV) were quantified to characterize tissue-level perfusion and large cerebral artery transit time properties, respectively. In repeat scanning, intraclass correlation (ICC) indicated moderate test-retest reliability for global gray matter CBF (ICC = 0.73) and excellent reliability for sCoV (ICC = 0.94). In the observational study, gray matter CBF increased after training (baseline: 40 ± 13 vs. 6-month: 46 ± 12 ml·100 g(−1)·min(−1), P = 0.036). The greatest change occurred in the parietal lobe (+18 ± 12%). Gray matter sCoV, however, did not change following training (P = 0.31). This study provides preliminary evidence that exercise-based rehabilitation in chronic stroke enhances tissue-level perfusion, without changing the relative hemodynamic properties of the large cerebral arteries. Frontiers Media S.A. 2017-09-29 /pmc/articles/PMC5626868/ /pubmed/29033829 http://dx.doi.org/10.3389/fnagi.2017.00318 Text en Copyright © 2017 Robertson, Marzolini, Middleton, Basile, Oh and MacIntosh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Robertson, Andrew D. Marzolini, Susan Middleton, Laura E. Basile, Vincenzo S. Oh, Paul I. MacIntosh, Bradley J. Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title_full | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title_fullStr | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title_full_unstemmed | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title_short | Exercise Training Increases Parietal Lobe Cerebral Blood Flow in Chronic Stroke: An Observational Study |
title_sort | exercise training increases parietal lobe cerebral blood flow in chronic stroke: an observational study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626868/ https://www.ncbi.nlm.nih.gov/pubmed/29033829 http://dx.doi.org/10.3389/fnagi.2017.00318 |
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