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Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis
Previous studies on congenital amusia mainly focused on the impaired fronto-temporal pathway. It is possible that neural pathways of amusia patients on a larger scale are affected. In this study, we investigated changes in structural connections by applying both tract-based and network-based analysi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626874/ https://www.ncbi.nlm.nih.gov/pubmed/29033806 http://dx.doi.org/10.3389/fnhum.2017.00473 |
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author | Wang, Jieqiong Zhang, Caicai Wan, Shibiao Peng, Gang |
author_facet | Wang, Jieqiong Zhang, Caicai Wan, Shibiao Peng, Gang |
author_sort | Wang, Jieqiong |
collection | PubMed |
description | Previous studies on congenital amusia mainly focused on the impaired fronto-temporal pathway. It is possible that neural pathways of amusia patients on a larger scale are affected. In this study, we investigated changes in structural connections by applying both tract-based and network-based analysis to DTI data of 12 subjects with congenital amusia and 20 demographic-matched normal controls. TBSS (tract-based spatial statistics) was used to detect microstructural changes. The results showed that amusics had higher diffusivity indices in the corpus callosum, the right inferior/superior longitudinal fasciculus, and the right inferior frontal-occipital fasciculus (IFOF). The axial diffusivity values of the right IFOF were negatively correlated with musical scores in the amusia group. Network-based analysis showed that the efficiency of the brain network was reduced in amusics. The impairments of WM tracts were also found to be correlated with reduced network efficiency in amusics. This suggests that impaired WM tracts may lead to the reduced network efficiency seen in amusics. Our findings suggest that congenital amusia is a disconnection syndrome. |
format | Online Article Text |
id | pubmed-5626874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56268742017-10-13 Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis Wang, Jieqiong Zhang, Caicai Wan, Shibiao Peng, Gang Front Hum Neurosci Neuroscience Previous studies on congenital amusia mainly focused on the impaired fronto-temporal pathway. It is possible that neural pathways of amusia patients on a larger scale are affected. In this study, we investigated changes in structural connections by applying both tract-based and network-based analysis to DTI data of 12 subjects with congenital amusia and 20 demographic-matched normal controls. TBSS (tract-based spatial statistics) was used to detect microstructural changes. The results showed that amusics had higher diffusivity indices in the corpus callosum, the right inferior/superior longitudinal fasciculus, and the right inferior frontal-occipital fasciculus (IFOF). The axial diffusivity values of the right IFOF were negatively correlated with musical scores in the amusia group. Network-based analysis showed that the efficiency of the brain network was reduced in amusics. The impairments of WM tracts were also found to be correlated with reduced network efficiency in amusics. This suggests that impaired WM tracts may lead to the reduced network efficiency seen in amusics. Our findings suggest that congenital amusia is a disconnection syndrome. Frontiers Media S.A. 2017-09-29 /pmc/articles/PMC5626874/ /pubmed/29033806 http://dx.doi.org/10.3389/fnhum.2017.00473 Text en Copyright © 2017 Wang, Zhang, Wan and Peng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wang, Jieqiong Zhang, Caicai Wan, Shibiao Peng, Gang Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title | Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title_full | Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title_fullStr | Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title_full_unstemmed | Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title_short | Is Congenital Amusia a Disconnection Syndrome? A Study Combining Tract- and Network-Based Analysis |
title_sort | is congenital amusia a disconnection syndrome? a study combining tract- and network-based analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626874/ https://www.ncbi.nlm.nih.gov/pubmed/29033806 http://dx.doi.org/10.3389/fnhum.2017.00473 |
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