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Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia

In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions. We previously developed a system named bridge-induced translocation (BIT) that allows linking together two different chromosomes exploiting the str...

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Detalles Bibliográficos
Autores principales:	Tosato, Valentina, West, Nicole, Zrimec, Jan, Nikitin, Dmitri V., Del Sal, Giannino, Marano, Roberto, Breitenbach, Michael, Bruschi, Carlo V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626878/ https://www.ncbi.nlm.nih.gov/pubmed/29034209 http://dx.doi.org/10.3389/fonc.2017.00231

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