In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells

Virus-based gene therapy by CRISPR/Cas9-mediated genome editing and knockout may provide a new option for treatment of inherited and acquired ocular diseases of the retina. In support of this notion, we show that Streptococcus pyogenes (Sp) Cas9, delivered by lentiviral vectors (LVs), can be used in...

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Detalles Bibliográficos
Autores principales: Holmgaard, Andreas, Askou, Anne Louise, Benckendorff, Josephine Natalia Esther, Thomsen, Emil Aagaard, Cai, Yujia, Bek, Toke, Mikkelsen, Jacob Giehm, Corydon, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626917/
https://www.ncbi.nlm.nih.gov/pubmed/29246327
http://dx.doi.org/10.1016/j.omtn.2017.08.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626917/
https://www.ncbi.nlm.nih.gov/pubmed/29246327
http://dx.doi.org/10.1016/j.omtn.2017.08.016

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