Rab GTPases in Immunity and Inflammation

Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of i...

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Detalles Bibliográficos
Autores principales: Prashar, Akriti, Schnettger, Laura, Bernard, Elliott M., Gutierrez, Maximiliano G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627064/
https://www.ncbi.nlm.nih.gov/pubmed/29034219
http://dx.doi.org/10.3389/fcimb.2017.00435
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author Prashar, Akriti
Schnettger, Laura
Bernard, Elliott M.
Gutierrez, Maximiliano G.
author_facet Prashar, Akriti
Schnettger, Laura
Bernard, Elliott M.
Gutierrez, Maximiliano G.
author_sort Prashar, Akriti
collection PubMed
description Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.
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spelling pubmed-56270642017-10-13 Rab GTPases in Immunity and Inflammation Prashar, Akriti Schnettger, Laura Bernard, Elliott M. Gutierrez, Maximiliano G. Front Cell Infect Microbiol Microbiology Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation. Frontiers Media S.A. 2017-09-29 /pmc/articles/PMC5627064/ /pubmed/29034219 http://dx.doi.org/10.3389/fcimb.2017.00435 Text en Copyright © 2017 Prashar, Schnettger, Bernard and Gutierrez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Prashar, Akriti
Schnettger, Laura
Bernard, Elliott M.
Gutierrez, Maximiliano G.
Rab GTPases in Immunity and Inflammation
title Rab GTPases in Immunity and Inflammation
title_full Rab GTPases in Immunity and Inflammation
title_fullStr Rab GTPases in Immunity and Inflammation
title_full_unstemmed Rab GTPases in Immunity and Inflammation
title_short Rab GTPases in Immunity and Inflammation
title_sort rab gtpases in immunity and inflammation
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627064/
https://www.ncbi.nlm.nih.gov/pubmed/29034219
http://dx.doi.org/10.3389/fcimb.2017.00435
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