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Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains

Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in Ca(V)1.1 and Ca(V)1.3 C...

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Detalles Bibliográficos
Autores principales:	Monteleone, Stefania, Lieb, Andreas, Pinggera, Alexandra, Negro, Giulia, Fuchs, Julian E., Hofer, Florian, Striessnig, Jörg, Tuluc, Petronel, Liedl, Klaus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2017
Materias:	Channels and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627182/ https://www.ncbi.nlm.nih.gov/pubmed/28978442 http://dx.doi.org/10.1016/j.bpj.2017.08.010

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