Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads

The bovine MHC (BoLA) class II DRB3 alleles are associated with polyclonal expansion of lymphocytes caused by bovine leukemia virus (BLV) infection in cattle. To examine whether the DRB3*0902 allele, one of the resistance-associated alleles, is associated with the proviral load, we measured BLV prov...

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Autores principales: HAYASHI, Takumi, MEKATA, Hirohisa, SEKIGUCHI, Satoshi, KIRINO, Yumi, MITOMA, Shuya, HONKAWA, Kazuyuki, HORII, Yoichiro, NORIMINE, Junzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627326/
https://www.ncbi.nlm.nih.gov/pubmed/28757522
http://dx.doi.org/10.1292/jvms.16-0601
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author HAYASHI, Takumi
MEKATA, Hirohisa
SEKIGUCHI, Satoshi
KIRINO, Yumi
MITOMA, Shuya
HONKAWA, Kazuyuki
HORII, Yoichiro
NORIMINE, Junzo
author_facet HAYASHI, Takumi
MEKATA, Hirohisa
SEKIGUCHI, Satoshi
KIRINO, Yumi
MITOMA, Shuya
HONKAWA, Kazuyuki
HORII, Yoichiro
NORIMINE, Junzo
author_sort HAYASHI, Takumi
collection PubMed
description The bovine MHC (BoLA) class II DRB3 alleles are associated with polyclonal expansion of lymphocytes caused by bovine leukemia virus (BLV) infection in cattle. To examine whether the DRB3*0902 allele, one of the resistance-associated alleles, is associated with the proviral load, we measured BLV proviral load of BLV-infected cattle and clarified their DRB3 alleles. Fifty-seven animals with DRB3*0902 were identified out of 835 BLV-infected cattle and had significantly lower proviral load (P<0.000001) compared with the rest of the infected animals, in both Japanese Black and Holstein cattle. This result strongly indicates that the BoLA class II DRA/DRB3*0902 molecule plays an important immunological role in suppressing viral replication, resulting in resistance to the disease progression.
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spelling pubmed-56273262017-10-10 Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads HAYASHI, Takumi MEKATA, Hirohisa SEKIGUCHI, Satoshi KIRINO, Yumi MITOMA, Shuya HONKAWA, Kazuyuki HORII, Yoichiro NORIMINE, Junzo J Vet Med Sci Virology The bovine MHC (BoLA) class II DRB3 alleles are associated with polyclonal expansion of lymphocytes caused by bovine leukemia virus (BLV) infection in cattle. To examine whether the DRB3*0902 allele, one of the resistance-associated alleles, is associated with the proviral load, we measured BLV proviral load of BLV-infected cattle and clarified their DRB3 alleles. Fifty-seven animals with DRB3*0902 were identified out of 835 BLV-infected cattle and had significantly lower proviral load (P<0.000001) compared with the rest of the infected animals, in both Japanese Black and Holstein cattle. This result strongly indicates that the BoLA class II DRA/DRB3*0902 molecule plays an important immunological role in suppressing viral replication, resulting in resistance to the disease progression. The Japanese Society of Veterinary Science 2017-07-28 2017-09 /pmc/articles/PMC5627326/ /pubmed/28757522 http://dx.doi.org/10.1292/jvms.16-0601 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Virology
HAYASHI, Takumi
MEKATA, Hirohisa
SEKIGUCHI, Satoshi
KIRINO, Yumi
MITOMA, Shuya
HONKAWA, Kazuyuki
HORII, Yoichiro
NORIMINE, Junzo
Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title_full Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title_fullStr Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title_full_unstemmed Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title_short Cattle with the BoLA class II DRB3*0902 allele have significantly lower bovine leukemia proviral loads
title_sort cattle with the bola class ii drb3*0902 allele have significantly lower bovine leukemia proviral loads
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627326/
https://www.ncbi.nlm.nih.gov/pubmed/28757522
http://dx.doi.org/10.1292/jvms.16-0601
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