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Light-responsive paper strips as CO-releasing material with a colourimetric response
Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-re...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627354/ https://www.ncbi.nlm.nih.gov/pubmed/28989681 http://dx.doi.org/10.1039/c7sc01692a |
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author | Reddy G., Upendar Liu, Jingjing Hoffmann, Patrick Steinmetzer, Johannes Görls, Helmar Kupfer, Stephan Askes, Sven H. C. Neugebauer, Ute Gräfe, Stefanie Schiller, Alexander |
author_facet | Reddy G., Upendar Liu, Jingjing Hoffmann, Patrick Steinmetzer, Johannes Görls, Helmar Kupfer, Stephan Askes, Sven H. C. Neugebauer, Ute Gräfe, Stefanie Schiller, Alexander |
author_sort | Reddy G., Upendar |
collection | PubMed |
description | Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC(50) ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye. |
format | Online Article Text |
id | pubmed-5627354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-56273542017-10-06 Light-responsive paper strips as CO-releasing material with a colourimetric response Reddy G., Upendar Liu, Jingjing Hoffmann, Patrick Steinmetzer, Johannes Görls, Helmar Kupfer, Stephan Askes, Sven H. C. Neugebauer, Ute Gräfe, Stefanie Schiller, Alexander Chem Sci Chemistry Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC(50) ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye. Royal Society of Chemistry 2017-09-01 2017-07-26 /pmc/articles/PMC5627354/ /pubmed/28989681 http://dx.doi.org/10.1039/c7sc01692a Text en This journal is © The Royal Society of Chemistry 2017 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Reddy G., Upendar Liu, Jingjing Hoffmann, Patrick Steinmetzer, Johannes Görls, Helmar Kupfer, Stephan Askes, Sven H. C. Neugebauer, Ute Gräfe, Stefanie Schiller, Alexander Light-responsive paper strips as CO-releasing material with a colourimetric response |
title | Light-responsive paper strips as CO-releasing material with a colourimetric response
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title_full | Light-responsive paper strips as CO-releasing material with a colourimetric response
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title_fullStr | Light-responsive paper strips as CO-releasing material with a colourimetric response
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title_full_unstemmed | Light-responsive paper strips as CO-releasing material with a colourimetric response
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title_short | Light-responsive paper strips as CO-releasing material with a colourimetric response
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title_sort | light-responsive paper strips as co-releasing material with a colourimetric response |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627354/ https://www.ncbi.nlm.nih.gov/pubmed/28989681 http://dx.doi.org/10.1039/c7sc01692a |
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