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Light-responsive paper strips as CO-releasing material with a colourimetric response

Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-re...

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Autores principales: Reddy G., Upendar, Liu, Jingjing, Hoffmann, Patrick, Steinmetzer, Johannes, Görls, Helmar, Kupfer, Stephan, Askes, Sven H. C., Neugebauer, Ute, Gräfe, Stefanie, Schiller, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627354/
https://www.ncbi.nlm.nih.gov/pubmed/28989681
http://dx.doi.org/10.1039/c7sc01692a
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author Reddy G., Upendar
Liu, Jingjing
Hoffmann, Patrick
Steinmetzer, Johannes
Görls, Helmar
Kupfer, Stephan
Askes, Sven H. C.
Neugebauer, Ute
Gräfe, Stefanie
Schiller, Alexander
author_facet Reddy G., Upendar
Liu, Jingjing
Hoffmann, Patrick
Steinmetzer, Johannes
Görls, Helmar
Kupfer, Stephan
Askes, Sven H. C.
Neugebauer, Ute
Gräfe, Stefanie
Schiller, Alexander
author_sort Reddy G., Upendar
collection PubMed
description Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC(50) ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye.
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spelling pubmed-56273542017-10-06 Light-responsive paper strips as CO-releasing material with a colourimetric response Reddy G., Upendar Liu, Jingjing Hoffmann, Patrick Steinmetzer, Johannes Görls, Helmar Kupfer, Stephan Askes, Sven H. C. Neugebauer, Ute Gräfe, Stefanie Schiller, Alexander Chem Sci Chemistry Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC(50) ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye. Royal Society of Chemistry 2017-09-01 2017-07-26 /pmc/articles/PMC5627354/ /pubmed/28989681 http://dx.doi.org/10.1039/c7sc01692a Text en This journal is © The Royal Society of Chemistry 2017 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Reddy G., Upendar
Liu, Jingjing
Hoffmann, Patrick
Steinmetzer, Johannes
Görls, Helmar
Kupfer, Stephan
Askes, Sven H. C.
Neugebauer, Ute
Gräfe, Stefanie
Schiller, Alexander
Light-responsive paper strips as CO-releasing material with a colourimetric response
title Light-responsive paper strips as CO-releasing material with a colourimetric response
title_full Light-responsive paper strips as CO-releasing material with a colourimetric response
title_fullStr Light-responsive paper strips as CO-releasing material with a colourimetric response
title_full_unstemmed Light-responsive paper strips as CO-releasing material with a colourimetric response
title_short Light-responsive paper strips as CO-releasing material with a colourimetric response
title_sort light-responsive paper strips as co-releasing material with a colourimetric response
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627354/
https://www.ncbi.nlm.nih.gov/pubmed/28989681
http://dx.doi.org/10.1039/c7sc01692a
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