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Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus

BACKGROUND: Ascomycin is a 23-membered polyketide macrolide with high immunosuppressant and antifungal activity. As the lower production in bio-fermentation, global metabolic analysis is required to further explore its biosynthetic network and determine the key limiting steps for rationally engineer...

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Detalles Bibliográficos
Autores principales:	Wang, Junhua, Wang, Cheng, Song, Kejing, Wen, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627430/ https://www.ncbi.nlm.nih.gov/pubmed/28974216 http://dx.doi.org/10.1186/s12934-017-0787-5

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