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History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA

BACKGROUND: Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by e...

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Autores principales: Mittal, Maria Luisa, Vashishtha, Devesh, Sun, Shelly, Jain, Sonia, Cuevas-Mota, Jazmine, Garfein, Richard, Strathdee, Steffanie A., Werb, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627474/
https://www.ncbi.nlm.nih.gov/pubmed/28974239
http://dx.doi.org/10.1186/s13011-017-0126-1
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author Mittal, Maria Luisa
Vashishtha, Devesh
Sun, Shelly
Jain, Sonia
Cuevas-Mota, Jazmine
Garfein, Richard
Strathdee, Steffanie A.
Werb, Dan
author_facet Mittal, Maria Luisa
Vashishtha, Devesh
Sun, Shelly
Jain, Sonia
Cuevas-Mota, Jazmine
Garfein, Richard
Strathdee, Steffanie A.
Werb, Dan
author_sort Mittal, Maria Luisa
collection PubMed
description BACKGROUND: Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by exposing injecting practices to injection-naïve drug users. Our primary objective was to test whether a history of MAT enrollment is associated with a reduced odds of PWID providing injection initiation assistance. METHODS: Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256–01), is a multi-site cohort study assessing the impact of socio-structural factors on the risk that PWID provide injection initiation assistance. Data were drawn from a participating cohort of PWID in San Diego, CA. The primary outcome was reporting ever providing injection initiation assistance; the primary predictor was reporting ever being enrolled in MAT. Logistic regression was used to model associations between MAT enrollment and ever initiating others into injecting while adjusting for potential confounders. RESULTS: Participants (n = 354) were predominantly male (n = 249, 70%). Thirty-eight percent (n = 135) of participants reported ever initiating others into injection drug use. In multivariate analysis, participants who reported a history of MAT enrollment had significantly decreased odds of ever providing injection initiation assistance (Adjusted Odds Ratio [AOR]: 0.62, 95% Confidence Interval [CI]: 0.39–0.99). CONCLUSIONS: These preliminary findings suggest an association between MAT enrollment and a lower odds that male PWID report providing injection initiation assistance to injection-naïve drug users. Further research is needed to identify the pathways by which MAT enrollment may impact the risk that PWID initiate others into drug injecting.
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spelling pubmed-56274742017-10-12 History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA Mittal, Maria Luisa Vashishtha, Devesh Sun, Shelly Jain, Sonia Cuevas-Mota, Jazmine Garfein, Richard Strathdee, Steffanie A. Werb, Dan Subst Abuse Treat Prev Policy Short Report BACKGROUND: Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by exposing injecting practices to injection-naïve drug users. Our primary objective was to test whether a history of MAT enrollment is associated with a reduced odds of PWID providing injection initiation assistance. METHODS: Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256–01), is a multi-site cohort study assessing the impact of socio-structural factors on the risk that PWID provide injection initiation assistance. Data were drawn from a participating cohort of PWID in San Diego, CA. The primary outcome was reporting ever providing injection initiation assistance; the primary predictor was reporting ever being enrolled in MAT. Logistic regression was used to model associations between MAT enrollment and ever initiating others into injecting while adjusting for potential confounders. RESULTS: Participants (n = 354) were predominantly male (n = 249, 70%). Thirty-eight percent (n = 135) of participants reported ever initiating others into injection drug use. In multivariate analysis, participants who reported a history of MAT enrollment had significantly decreased odds of ever providing injection initiation assistance (Adjusted Odds Ratio [AOR]: 0.62, 95% Confidence Interval [CI]: 0.39–0.99). CONCLUSIONS: These preliminary findings suggest an association between MAT enrollment and a lower odds that male PWID report providing injection initiation assistance to injection-naïve drug users. Further research is needed to identify the pathways by which MAT enrollment may impact the risk that PWID initiate others into drug injecting. BioMed Central 2017-10-03 /pmc/articles/PMC5627474/ /pubmed/28974239 http://dx.doi.org/10.1186/s13011-017-0126-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Mittal, Maria Luisa
Vashishtha, Devesh
Sun, Shelly
Jain, Sonia
Cuevas-Mota, Jazmine
Garfein, Richard
Strathdee, Steffanie A.
Werb, Dan
History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title_full History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title_fullStr History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title_full_unstemmed History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title_short History of medication-assisted treatment and its association with initiating others into injection drug use in San Diego, CA
title_sort history of medication-assisted treatment and its association with initiating others into injection drug use in san diego, ca
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627474/
https://www.ncbi.nlm.nih.gov/pubmed/28974239
http://dx.doi.org/10.1186/s13011-017-0126-1
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